Targeting brain microvascular endothelial cells: a therapeutic approach to neuroprotection against stroke.
Targeting brain microvascular endothelial cells: a therapeutic approach to neuroprotection against stroke.
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靶向脑微血管内皮细胞：针对中风的神经保护的治疗方法
DOI：
10.4103/1673-5374.170324
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发表时间：
2015-11
影响因子：
6.1
通讯作者：
Li MC
中科院分区：
文献类型：
--
作者：
Yu QJ;Tao H;Wang X;Li MC
脑微血管内皮细胞是神经组织和循环血液之间的界面，调节中枢神经系统的稳态。脑微血管内皮细胞与外周内皮细胞在表达特异性离子转运蛋白和受体方面不同，并且含有较少的开窗和胞饮小泡。脑微血管内皮细胞还合成影响血管功能的几种因子。本文综述了脑微血管内皮细胞的形态学特征和功能，并总结了目前的知识，脑微血管内皮细胞的变化在中风的进展和治疗。未来的研究应该集中在确定这种变化的机制和开发可能的神经保护治疗干预。
Brain microvascular endothelial cells form the interface between nervous tissue and circulating blood, and regulate central nervous system homeostasis. Brain microvascular endothelial cells differ from peripheral endothelial cells with regards expression of specific ion transporters and receptors, and contain fewer fenestrations and pinocytotic vesicles. Brain microvascular endothelial cells also synthesize several factors that influence blood vessel function. This review describes the morphological characteristics and functions of brain microvascular endothelial cells, and summarizes current knowledge regarding changes in brain microvascular endothelial cells during stroke progression and therapies. Future studies should focus on identifying mechanisms underlying such changes and developing possible neuroprotective therapeutic interventions.