RECURRENCE OF CHOROIDAL NEOVASCULARIZATION LESION ACTIVITY AFTER AFLIBERCEPT TREATMENT FOR AGE-RELATED MACULAR DEGENERATION
RECURRENCE OF CHOROIDAL NEOVASCULARIZATION LESION ACTIVITY AFTER AFLIBERCEPT TREATMENT FOR AGE-RELATED MACULAR DEGENERATION
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DOI：
10.1097/iae.0000000000001451
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发表时间：
2017-11-01
影响因子：
3.3
通讯作者：
Yoshimura, Nagahisa
中科院分区：
文献类型：
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作者：
Wakazono, Tomotaka;Yamashiro, Kenji;Yoshimura, Nagahisa
目的：研究年龄相关性黄斑变性（AMD）脉络膜新生血管（CNV）病变活动的复发率及aflibercept治疗1年后的相关因素。方法：回顾性评价接受aflibercept固定方案治疗1年的AMD相关性黄斑变性眼睛，并对首次注射aflibercept治疗的渗出性AMD进行至少18个月的随访。检查复发率。比较复发眼与未复发眼的年龄、性别、视力、AMD亚型、最大线性尺寸以及12个月检查时视网膜和脉络膜厚度。息肉状脉络膜血管病变（PCV）eyes.Results的残留息肉和色素上皮脱离（PED）形态的存在也进行了比较：在98只眼睛的研究，69显示在第12个月检查干黄斑; 43.7%的复发在随后的12个月期间在Kaplan-Meier分析。虽然没有相关因素与复发检测AMD，残留息肉和色素上皮脱落形态在第12个月的检查与息肉状脉络膜血管病变复发显着相关（P = 0.018和0.048，分别）。结论：连续，积极的治疗将被认为是过度治疗超过一半的AMD眼睛，实现了干黄斑。血管造影和光学相干断层扫描分析可能有助于预测息肉状脉络膜血管病变的复发。
Purpose: To examine the recurrence rate of choroidal neovascularization (CNV) lesion activity in age-related macular degeneration (AMD) and associated factors after 1-year aflibercept treatment.Methods: Age-related macular degeneration eyes with 1-year aflibercept fixed-regimen treatment and a follow-up period of at least 18 months from the initial aflibercept injection for treatment-naive exudative AMD were retrospectively evaluated. The recurrence rate was examined. Age, gender, visual acuity, AMD subtype, greatest linear dimension, and retinal and choroidal thicknesses at the 12th month examination were compared between eyes with and without recurrence. Presence of remnant polyps and pigment epithelial detachment (PED) morphology were also compared in polypoidal choroidal vasculopathy (PCV) eyes.Results: Of the 98 eyes studied, 69 displayed a dry macula at the 12th month examination; 43.7% exhibited recurrence during the subsequent 12-month period in Kaplan-Meier analysis. Although no factors associated with recurrence were detected in AMD, remnant polyps and pigment epithelial detachment morphology at the 12th month examination were significantly associated with recurrence in polypoidal choroidal vasculopathy (P = 0.018 and 0.048, respectively).Conclusion: Continuous, proactive treatment would be considered overtreatment for more than half of the AMD eyes that achieved a dry macula. Angiography and optical coherence tomography analyses may be useful for predicting recurrence in polypoidal choroidal vasculopathy eyes.