12-month mortality and loss-to-program in antiretroviral-treated children: The IeDEA pediatric West African Database to evaluate AIDS (pWADA), 2000-2008.
12-month mortality and loss-to-program in antiretroviral-treated children: The IeDEA pediatric West African Database to evaluate AIDS (pWADA), 2000-2008.
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DOI：
10.1186/1471-2458-11-519
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发表时间：
2011-06-30
影响因子：
4.5
通讯作者：
IeDEA pediatric West Africa Working Group pWADA
中科院分区：
文献类型：
--
作者：
Ekouevi DK;Azondekon A;Dicko F;Malateste K;Touré P;Eboua FT;Kouadio K;Renner L;Peterson K;Dabis F;Sy HS;Leroy V;IeDEA pediatric West Africa Working Group pWADA
2007年1月成立了西非儿科工作组，研究该地区艾滋病毒感染儿童的护理和治疗。我们在这里描述的特点，在抗逆转录病毒治疗（ART）的启动和研究12个月的死亡率和损失的艾滋病毒感染的儿童在西非的ART计划。标准化的数据，从艾滋病毒感染的儿童随访的抗逆转录病毒治疗计划。来自6个国家（贝宁、科特迪瓦、冈比亚、加纳、马里和塞内加尔）的9个临床中心为数据集提供了资料。入选标准如下：年龄0-15岁，开始三联抗逆转录病毒药物治疗方案。基线时间是ART开始的日期。根据年龄或CD 4百分比<15%的CD 4计数，使用WHO标准定义严重免疫抑制。我们估计了ART启动后12个月的死亡率和失访（死亡或失访> 6个月）的Kaplan-Meier概率以及与这两种结局相关的因素。在2000年6月至2007年12月期间，有2 170名儿童被纳入。ART启动时的特征如下：中位年龄为5岁（四分位数间距（IQR：2-9）），中位CD 4百分比为13%（IQR：7-19）。最常见的药物方案包括两种核苷类逆转录酶抑制剂和一种非核苷类逆转录酶抑制剂（62%）。在最初的12个月里，169名（7.8%）儿童死亡，461名（21.2%）儿童失去了计划。总体而言，在接受抗逆转录病毒治疗的艾滋病毒感染儿童中，12个月的死亡概率为8.3%（95%置信区间（CI）：7.2-9.6%），丧失计划的概率为23.1%（95% CI：21.3-25.0%）。死亡率和计划失败率均与晚期临床分期、ART启动时CD 4百分比< 15%和ART启动年份（> 2005年）相关。需要采取创新和可持续的方法，以更好地记录死亡原因，并增加西非艾滋病毒儿科诊所的保留率。
The IeDEA West Africa Pediatric Working Group (pWADA) was established in January 2007 to study the care and treatment of HIV-infected children in this region. We describe here the characteristics at antiretroviral treatment (ART) initiation and study the 12-month mortality and loss-to-program of HIV-infected children followed in ART programs in West Africa. Standardized data from HIV-infected children followed-up in ART programs were included. Nine clinical centers from six countries contributed to the dataset (Benin, Côte d'Ivoire, Gambia, Ghana, Mali and Senegal). Inclusion criteria were the followings: age 0-15 years and initiated triple antiretroviral drug regimens. Baseline time was the date of ART initiation. WHO criteria was used to define severe immunosuppression based on CD4 count by age or CD4 percent < 15%. We estimated the 12-month Kaplan-Meier probabilities of mortality and loss-to-program (death or loss to follow-up > 6 months) after ART initiation and factors associated with these two outcomes. Between June 2000 and December 2007, 2170 children were included. Characteristics at ART initiation were the following: median age of 5 years (Interquartile range (IQR: 2-9) and median CD4 percentage of 13% (IQR: 7-19). The most frequent drug regimen consisted of two nucleoside reverse transcriptase inhibitors and one non-nucleoside reverse transcriptase inhibitors (62%). During the first 12 months, 169 (7.8%) children died and 461(21.2%) were lost-to-program. Overall, in HIV-infected children on ART, the 12-month probability of death was 8.3% (95% Confidence Interval (CI): 7.2-9.6%), and of loss-to-program was 23.1% (95% CI: 21.3-25.0%). Both mortality and loss-to program were associated with advanced clinical stage, CD4 percentage < 15% at ART initiation and year (> 2005) of ART initiation. Innovative and sustainable approaches are needed to better document causes of death and increase retention in HIV pediatric clinics in West Africa.
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影响因子：
3.8
作者：
Fassinou, P;Elenga, N;Msellati, P
通讯作者：
Msellati, P
影响因子：
3.3
作者：
Tonwe-Gold, B.;Ekouevi, D. K.;Abrams, E. J.
通讯作者：
Abrams, E. J.
DOI：
10.2471/blt.09.068015
发表时间：
2010-07-01
期刊：
Bulletin of the World Health Organization: International Journal of Public Health
影响因子：
--
作者：
Anaky, M-F;Duvignac, J;Leroy, V
通讯作者：
Leroy, V
影响因子：
3.6
作者：
Creek, Tracy;Tanuri, Amilcar;Shaffer, Nathan
通讯作者：
Shaffer, Nathan
DOI：
10.2471/blt.07.044248
发表时间：
2008-07-01
期刊：
Bulletin of the World Health Organization: International Journal of Public Health
影响因子：
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作者：
Brinkhof, Martin WG;Dabis, François;Anglaret, Xavier
通讯作者：
Anglaret, Xavier