Interaction between the mGlu receptors 5 antagonist, MPEP, and amphetamine on memory and motor functions in mice
Interaction between the mGlu receptors 5 antagonist, MPEP, and amphetamine on memory and motor functions in mice
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mGlu 受体 5 拮抗剂、MPEP 和安非他明之间的相互作用对小鼠记忆和运动功能的影响
作者：
F. Managò;S. Lopez;A. Oliverio;M. Amalric;A. Mele;E. Leonibus
代谢型谷氨酸mGlu受体5（mGluR 5）受体在皮质边缘回路中大量存在，并参与调节谷氨酸和多巴胺的信号转导。（2-甲基-6-（苯乙炔基）吡啶盐酸盐）（MPEP）促进多巴胺依赖性对记忆和运动功能的作用。我们研究了不同剂量的（0至24 mg/kg）的mGluR 5拮抗剂MPEP对安非他明依赖性行为的调节，即被动回避，运动活动，和旋转行为在完整的和多巴胺耗尽的CD 1雄性小鼠。结果我们证明，低剂量（3 mg/kg）的MPEP，这是无效的行为影响本身，促进安非他明诱导的影响独立的行为测量在天真的和多巴胺损伤的小鼠;这种协同效应是失去了更高剂量的MPEP是used.ConclusionThe结果进行了讨论，在调节适当的微调信息处理多巴胺和谷氨酸活性之间的可能的平衡。
RationaleMetabotropic glutamate mGlu receptors 5 (mGluR5) receptors are abundant in corticolimbic circuitry where they modulate glutamate and dopamine signal transduction.ObjectivesIn this study, we explored the hypothesis that mGluR5 antagonist, (2-methyl-6-(phenylethynyl)pyridine hydrochloride) (MPEP), facilitates dopamine-dependent effects on memory and motor functions.MethodsTo this aim, we examined the effects of different doses (from 0 to 24 mg/kg) of the mGluR5 antagonist, MPEP, on the modulation of amphetamine-dependent behaviors, namely passive avoidance, locomotor activity, and rotation behavior in intact and dopamine-depleted CD1 male mice.ResultsWe demonstrated that a low dose (3 mg/kg) of MPEP, which is void of behavioral effects on its own, facilitates amphetamine-induced effects independently on the behavior measured both in naïve and in dopamine-lesioned mice; this synergistic effect is lost when higher doses of MPEP are used.ConclusionThe results are discussed in terms of possible balance between dopamine and glutamate activity in regulating the proper fine tuning of information processing.
影响因子：
5.2
作者：
M. Laruelle;L. Kegeles;A. Abi-Dargham
通讯作者：
M. Laruelle;L. Kegeles;A. Abi-Dargham
影响因子：
2.5
作者：
Homayoun, L;Jackson, ME;Moghaddam, B
通讯作者：
Moghaddam, B
DOI：
10.1073/pnas.0308618100
发表时间：
2004-02-24
影响因子：
11.1
作者：
Chen, GJ;Greengard, P;Yan, Z
通讯作者：
Yan, Z