Serum Lipids and Lipoproteins in Children from Families with Early Coronary Heart Disease*
Serum Lipids and Lipoproteins in Children from Families with Early Coronary Heart Disease*
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早期冠心病家庭儿童的血清脂质和脂蛋白*
DOI：
10.1136/adc.47.255.808
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发表时间：
1972
影响因子：
5.2
通讯作者：
B. Werbin
中科院分区：
文献类型：
--
作者：
I. Tamir;Y. Bojanower;O. Levtow;D. Heldenberg;Z. Dickerman;B. Werbin
对 64 名 41 岁以下、心肌梗死后存活超过 6 个月的男性及其子女的血清脂质和脂蛋白进行了调查。 26 名父亲及其所有 55 名孩子的血清脂质和脂蛋白模式均正常。 38名父亲的血脂浓度正常，但脂蛋白模式异常；其中，23人患有高β-脂蛋白血症，11人β-和前β-脂蛋白均升高，4人仅前β-脂蛋白升高。父亲脂蛋白异常的 85 名儿童中，有 30 名被发现患有 II 型高脂蛋白血症，无论父亲患有何种类型的高脂蛋白血症。父亲患有高β-脂蛋白血症的孩子中脂蛋白异常的发生率最高。
Serum lipids and lipoproteins of 64 men under the age of 41 years who survived for more than 6 months after a myocardial infarction, and of their children were investigated. 26 fathers and all their 55 children had normal serum lipids and lipoprotein patterns. 38 fathers had normal serum lipid concentration and abnormal lipoprotein pattern; of these, 23 had hyper-β-lipoproteinaemia, 11 had increase in both β- and pre-β-lipoprotein, and 4 had increase in pre-β-lipoprotein only. 30 of the 85 children whose fathers had abnormal lipoproteins were found to have type II hyperlipoproteinaemia regardless of the class of hyperlipaemia found in the father. The greatest incidence of lipoprotein abnormality was found in children of fathers of hyper-β-lipoproteinaemia.