The transcriptional repressor snail promotes mammary tumor recurrence
The transcriptional repressor snail promotes mammary tumor recurrence
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DOI：
10.1016/j.ccr.2005.07.009
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发表时间：
2005-09-01
期刊：
影响因子：
50.3
通讯作者：
Chodosh, LA
中科院分区：
文献类型：
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作者：
Moody, SE;Perez, D;Chodosh, LA
乳腺癌复发是肿瘤进展的基本临床表现，代表了这种疾病死亡的主要原因。使用条件转基因小鼠模型以HER2/NEU诱导的乳腺肿瘤的复发，我们证明了转录抑制剂蜗牛在体内复发性肿瘤中自发上调，并且这种复发伴随着上皮性 - 质质转换（EMT）。与蜗牛在这些过程中的因果作用一致，我们表明蜗牛足以诱导原发性肿瘤细胞中的EMT，蜗牛足以促进体内乳腺肿瘤复发，并且高水平的蜗牛预测，蜗牛预测降低了无复发的生存率。乳腺癌的妇女。总体而言，我们的观察结果强烈暗示蜗牛在乳腺癌复发的过程中。
Breast cancer recurrence is a fundamental clinical manifestation of tumor progression and represents the principal cause of death from this disease. Using a conditional transgenic mouse model for the recurrence of HER2/neu-induced mammary tumors, we demonstrate that the transcriptional repressor Snail is spontaneously upregulated in recurrent tumors in vivo and that recurrence is accompanied by epithelial-to-mesenchymal transition (EMT). Consistent with a causal role for Snail in these processes, we show that Snail is sufficient to induce EMT in primary tumor cells, that Snail is sufficient to promote mammary tumor recurrence in vivo, and that high levels of Snail predict decreased relapse-free survival in women with breast cancer. In aggregate, our observations strongly implicate Snail in the process of breast cancer recurrence.