Salbutamol inhalation in chronic asthma bronchiale: dose aerosol vs jet nebulizer.
Salbutamol inhalation in chronic asthma bronchiale: dose aerosol vs jet nebulizer.
复制标题
沙丁胺醇吸入治疗慢性支气管哮喘：剂量气雾剂与喷射雾化器。
作者：
P. Christensson;M. Arborelius;Bo Lilja
对20例慢性支气管哮喘患者进行了沙丁胺醇5mg喷射雾化吸入和0.3mg定量雾化吸入的疗效比较。随机选择的一半患者在第一天接受一种治疗方法，另一种在第二天接受。一组适用于检测大小气道阻塞的肺功能试验显示，使用喷射雾化器后，支气管扩张仅无显著性增加。用这种方法扩张小气道的效果也不明显。得出的结论是，喷射雾化器的较高剂量仅在患者无法进行有效使用剂量气雾剂所需的深吸入和屏气时才有临床动机。
The effect of inhalation of 5 mg of salbutamol by a jet nebulizer and 0.3 mg from a metered aerosol was compared in 20 patients with chronic asthma. Half the patients, randomly selected, received one treatment method on day one and the other on day two. A battery of lung function tests suitable for detecting large and small airways obstruction showed only insignificantly more pronounced bronchodilatation after the use of the jet nebulizer. Neither was a better dilation of small airways with this method obvious. It is concluded that the higher dose by jet-nebulizer is only clinically motivated when the patients cannot perform the deep inhalations and breathholding necessary for efficient use of the dose aerosol.