The Oral Microbiome
The Oral Microbiome
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DOI：
10.1128/9781555817107.ch2
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Kanitsak Boonanantanasarn;S. Gill
中科院分区：
文献类型：
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作者：
Kanitsak Boonanantanasarn;S. Gill
本章总结了我们对健康口腔微生物组知识的最新进展，并探讨了口腔微生物组在心血管疾病和肺炎等全身性疾病中的潜在作用。了解与口腔健康相关的口腔微生物群落的组成对于口腔疾病的诊断、预防和治疗至关重要。本章介绍了与牙周病相关的口腔微生物组、与牙髓感染、根尖周炎和蛀牙相关的微生物组，以及与口腔癌相关的口腔微生物组。由口腔微生物组引起的疾病不仅限于口腔感染。认识到与口腔微生物组相关的疾病会导致全身感染，可能需要临床医生考虑替代的预防和治疗方法。本章回顾了心血管和呼吸系统疾病这两种研究最多的全身性疾病的当前数据。本章讨论了基于群落和微生物生态学的致病概念，该概念构成了理解口腔微生物组与宿主之间关系以及制定新的治疗和疾病预防策略的基础。需要更好地了解口腔微生物组的结构和功能以及共生体和病原体之间的动态，以选择性地调节微生物组的组成并预防口腔疾病。
This chapter summarizes the recent advancement of our knowledge of the healthy oral microbiome, and address the potential role of the oral microbiome in systemic diseases, including cardiovascular disease and pneumonia. An understanding of the composition of the oral microbial community with respect to oral health is essential for diagnosis, prevention, and treatment of oral diseases. The chapter describes oral microbiome associated with periodontal disease, microbiome associated with endodontic infections, apical periodontitis and tooth decay, and oral microbiome associated with oral cancer. Diseases caused by the oral microbiome are not limited to oral infections. Recognition that disease conditions associated with the oral microbiome contribute to systemic infections may require clinicians to consider alternative preventative and therapeutic approaches. The current data on two of the most-studied systemic conditions, cardiovascular and respiratory diseases are reviewed in the chapter. A community-and microbial ecology-based pathogenic concept that forms the basis for understanding relationships between the oral microbiome and the host, as well as developing novel strategies for therapeutics and disease prevention is discussed in the chapter. A better understanding of the oral microbiome structure and function and the dynamics between the commensals and pathogens is needed to selectively modulate composition of the microbiome and prevent oral disease.