Is concordance with World Cancer Research Fund/American Institute for Cancer Research guidelines for cancer prevention related to subsequent risk of cancer? Results from the EPIC study
Is concordance with World Cancer Research Fund/American Institute for Cancer Research guidelines for cancer prevention related to subsequent risk of cancer? Results from the EPIC study
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DOI：
10.3945/ajcn.111.031674
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发表时间：
2012-07-01
影响因子：
7.1
通讯作者：
Norat, Teresa
中科院分区：
文献类型：
--
作者：
Romaguera, Dora;Vergnaud, Anne-Claire;Norat, Teresa
背景：2007年，世界癌症研究基金会(WCRF)和美国癌症研究所(AICR)在最全面收集现有证据的基础上，发布了关于癌症预防的饮食、体力活动和体重控制的8项建议(外加2项特别建议)。目的：我们旨在调查在欧洲癌症与营养前瞻性调查(EPIC)研究中，与WCRF/AICR建议的一致性是否与癌症风险有关。设计：本研究包括来自9个欧洲国家的386,355名EPIC参与者。在招募时，收集了饮食、人体测量和生活方式信息。根据WCRF/AICR关于体重管理、体力活动、促进体重增加的食品和饮料、植物食品、动物性食品、酒精饮料和女性母乳喂养的建议，构建了一个分数；男性的分数范围为0-6，女性的分数范围为0-7。得分越高，表明与WCRF/AICR建议的一致性越高。用多变量Cox回归模型估计得分与癌症风险之间的关系。结果：得分与得分的一致性与癌症风险的降低显著相关。得分每增加1分，总体癌症风险降低5%(95%CI：3%，7%)，结直肠癌风险降低12%(95%CI：9%，16%)，胃癌风险降低16%(95%CI：9%，22%)。乳腺癌、子宫内膜癌、肺癌、肾癌、上呼吸道癌、肝癌和食道癌也有显著的相关性，而前列腺癌、卵巢癌、胰腺癌和膀胱癌则没有相关性。结论：遵循WCRF/AICR的癌症预防建议可能会降低大多数类型癌症的风险。AM J Clin Nutr 2012；96：150-63。
Background: In 2007 the World Cancer Research Fund (WCRF) and the American Institute of Cancer Research (AICR) issued 8 recommendations (plus 2 special recommendations) on diet, physical activity, and weight management for cancer prevention on the basis of the most comprehensive collection of available evidence.Objective: We aimed to investigate whether concordance with the WCRF/AICR recommendations was related to cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study.Design: The present study included 386,355 EPIC participants from 9 European countries. At recruitment, dietary, anthropometric, and lifestyle information was collected. A score was constructed based on the WCRF/AICR recommendations on weight management, physical activity, foods and drinks that promote weight gain, plant foods, animal foods, alcoholic drinks, and breastfeeding for women; the score range was 0-6 for men and 0-7 for women. Higher scores indicated greater concordance with WCRF/AICR recommendations. The association between the score and cancer risk was estimated by using multivariable Cox regression models.Results: Concordance with the score was significantly associated with decreased risk of cancer. A 1-point increment in the score was associated with a risk reduction of 5% (95% Cl: 3%, 7%) for total cancer, 12% (95% CI: 9%, 16%) for colorectal cancer, and 16% (95% CI: 9%, 22%) for stomach cancer. Significant associations were also observed for cancers of the breast, endometrium, lung, kidney, upper aerodigestive tract, liver, and esophagus but not for prostate, ovarian, pancreatic, and bladder cancers.Conclusion: Adherence to the WCRF/AICR recommendations for cancer prevention may lower the risk of developing most types of cancer. Am J Clin Nutr 2012;96:150-63.