EFFECTS OF DEXAMETHASONE ON BODY-FLUID AND ELECTROLYTE-COMPOSITION OF RATS
EFFECTS OF DEXAMETHASONE ON BODY-FLUID AND ELECTROLYTE-COMPOSITION OF RATS
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DOI：
10.1530/acta.0.1220599
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发表时间：
1990-05-01
期刊：
影响因子：
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通讯作者：
DAVIES, DL
中科院分区：
文献类型：
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作者：
KENYON, CJ;BROWN, WB;DAVIES, DL
低剂量地塞米松输注（2 μ g/天，持续2周和4周）增加雄性大鼠的收缩压并降低体重增加。地塞米松治疗增加了全身钠、钙和镁;钾不受影响。考虑到糖皮质激素具有深刻的分解代谢作用，对这些变化进行了评价。相对于给药前的值，地塞米松降低了治疗前两周的可交换体钠，尽管值与溶剂处理的对照组无显著差异。地塞米松可增加红细胞压积、血浆胆固醇和转氨酶活性;降低白色细胞数量和血浆体积;对血浆Na+、K+和Ca 2+、红细胞数量、细胞外液体积和肾小球滤过率无显著影响。它的结论是，糖皮质激素导致血浆容量收缩，可能是由于糖皮质激素诱导的钠尿。地塞米松对全身离子组成的任何影响都被中间代谢的同时变化所掩盖。
Low-dose infusions of dexamethasone (2 .mu.g/day for 2 and 4 weeks) increased systolic blood pressure and decreased body weight gain in male rats. Total body sodium, calcium and magnesium were increased by dexamethasone treatment: potassium was unaffected. These changes have been evaluated bearing in mind that glucocorticoids have profound catabolic effects. Relative to pretreatment values, dexamethasone decreased exchangeable body sodium for the first two weeks of treatment although values were not significantly different from vehicle-treated controls. Hematocrit, plasma cholesterol and transaminase activities were increased by dexamethasone; white cell numbers and plasma volumes were decreased; plasma Na+, K+ and Ca2+, red cell numbers, extracellular fluid volume, and glomerular filtration rate were not significantly affected. It is concluded that glucocorticoids cause plasma volume to contract, possibly as a result of glucocorticoid-induced natriuresis. Any effects of dexamethasone on whole-body ionic composition are obscured by simultaneous changes of intermediary metabolism.