Visceral motor neuron diversity delineates a cellular basis for nipple- and pilo-erection muscle control
Visceral motor neuron diversity delineates a cellular basis for nipple- and pilo-erection muscle control
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DOI：
10.1038/nn.4376
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发表时间：
2016-10-01
影响因子：
25
通讯作者：
Ernfors, Patrik
中科院分区：
文献类型：
--
作者：
Furlan, Alessandro;La Manno, Gioele;Ernfors, Patrik
Despite the variety of physiological and target-related functions, little is known regarding the cellular complexity in the sympathetic ganglion. We explored the heterogeneity of mouse stellate and thoracic ganglia and found an unexpected variety of cell types. We identified specialized populations of nipple- and pilo-erector muscle neurons. These neurons extended axonal projections and were born among other neurons during embryogenesis, but remained unspecialized until target organogenesis occurred postnatally. Target innervation and cell-type specification was coordinated by an intricate acquisition of unique combinations of growth factor receptors and the initiation of expression of concomitant ligands by the nascent erector muscles. Overall, our results provide compelling evidence for a highly sophisticated organization of the sympathetic nervous system into discrete outflow channels that project to well-defined target tissues and offer mechanistic insight into how diversity and connectivity are established during development.
