Intraoperative Local Field Recording for Deep Brain Stimulation in Parkinson's Disease and Essential Tremor
Intraoperative Local Field Recording for Deep Brain Stimulation in Parkinson's Disease and Essential Tremor
复制标题
DOI：
10.1002/mds.23232
复制
发表时间：
2010-10-15
影响因子：
8.6
通讯作者：
Greene, Karl A.
中科院分区：
文献类型：
--
作者：
Holdefer, Robert N.;Cohen, Bernard A.;Greene, Karl A.
β频率范围（β-LFP）的振荡广泛分布在整个运动系统中，由多巴胺能药物调节，并在丘脑底核（STN）和丘脑腹侧中间核（VIM）中局部产生。我们研究了在深部脑刺激 (DBS) 手术期间记录术中 β-LFP 信号及其描述性汇总统计数据的可行性。来自帕金森病患者 STN 的微电极和刺激引线的 β-LFP 以及帕金森病或特发性震颤患者 VIM 中的刺激引线。 beta-LFP 功率在 8 秒的时间段内获得，并以压缩光谱和密度阵列以及趋势图的形式在线显示。与其他研究一致，与核背侧和腹侧的位点相比，STN 中沿微电极穿透的 β-LFP 功率更大。 STN 和 VIM 中刺激引线的接触处也观察到 b-LFP 功率的差异。具有最大 β-LFP 功率的接触点要么是临床刺激最有效的接触点，要么是与其相邻的接触点。这些结果是通过术中神经监测常用设备的传统功率测量、光谱显示和趋势图获得的。我们得出的结论是，β-LFP 是一种术中可获取且易于记录的信号，对于 DBS 导线定位和刺激导线的临床编程具有潜在的用途。 (C) 2010 运动障碍协会
Oscillations in the beta frequency range (beta-LFP) are widely distributed throughout the motor system, modulated by dopaminergic medications, and locally generated in the subthalamic nucleus (STN) and ventral intermediate nucleus of the thalamus (VIM). We investigated the feasibility of recording intraoperative beta-LFP signals and their descriptive summary statistics during surgeries for deep brain stimulation (DBS). beta-LFP from the microelectrode and stimulating lead were obtained from the STN in Parkinson's patients, and from the stimulating lead in the VIM of patients with Parkinson's disease or essential tremor. beta-LFP power was obtained over 8 second epochs and displayed online as compressed spectral and density arrays and trend plots. In agreement with other studies, beta-LFP power along microelectrode penetrations was greater in the STN as compared to sites dorsal and ventral to the nucleus. Differences in b-LFP power were also observed across the contacts of stimulating leads in the STN and VIM. The contact with greatest beta-LFP power was either the most effective contact for clinical stimulation or adjacent to it. These results were obtained from conventional power measurements, spectral displays, and trend plots with equipment commonly used for intraoperative neuro-monitoring. We conclude that beta-LFP is an accessible and easily recorded signal intraoperatively with potential usefulness for DBS lead localization and clinical programming of the stimulating lead. (C) 2010 Movement Disorder Society