Female age affects the utility of sperm DNA fragmentation in predicting IVF and ICSI outcomes
Female age affects the utility of sperm DNA fragmentation in predicting IVF and ICSI outcomes
复制标题
女性年龄影响精子 DNA 碎片在预测 IVF 和 ICSI 结果中的效用
DOI：
10.1016/j.rbmo.2019.09.013
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发表时间：
2019-12-01
影响因子：
4
通讯作者：
Yan, Jiexi
中科院分区：
文献类型：
--
作者：
Liang, Xiaolei;Mao, Yifang;Yan, Jiexi
研究问题：本研究的目的是探讨女性年龄如何影响精子DNA片段化指数（DFI）对辅助生殖技术临床结局的预测作用。设计：共招募和调查了2371名患者，包括2115名DFI正常的男性（30），256名DFI高的男性（>30）和不同年龄的女性。所有患者的染色体核型均正常，并正在接受首次新鲜IVF或卵胞浆内单精子注射（ICSI）周期。根据两个DFI组和女性年龄30岁分析临床结局。进行二元逻辑回归分析以确定与临床结果相关的因素。结果：DFI 30组中至少拥有一个优质胚胎的夫妇比例。当女性年龄大于30岁时，DFI >30组的临床妊娠率和优质胚胎夫妇比例低于DFI 30组，女性年龄诊断临床妊娠的临界值为30.5岁，敏感性为62.0%，特异性为63.6%。DFI >30组的临床妊娠率和优质胚胎的比例低于DFI组
Research question: The aim of this study was to investigate how female age affects the predictive effect of sperm DNA fragmentation index (DFI) on clinical outcomes with assisted reproductive technology.Design: A total of 2371 patients, comprising 2115 men with a normal DFI (30), 256 men with a high DFI (>30) and women of different ages, were recruited and investigated. All patients had normal chromosome karyotypes and were undergoing their first fresh IVF or intracytoplasmic sperm injection (ICSI) cycles. Clinical outcomes were analysed according to the two DFI groups and female age 30 years. Binary logistic regression analysis was performed to identify factors associated with clinical outcome.Results: The proportion of couples with at least one good-quality embryo in the DFI 30 group. When female age exceeded 30 years, clinical pregnancy rate and the proportion of couples with good-quality embryos in the DFI >30 group were lower compared with DFI 30, the cut-off value of female age was 30.5 for detecting clinical pregnancy; the sensitivity was 62.0%, and the specificity was 63.6%. Clinical pregnancy rate and proportion of couples with good-quality embryos were lower in the DFI >30 versus DFI