A feces collection paper does not enhance participation in a fecal immunochemical test-based colorectal cancer screening program: randomized clinical trial
A feces collection paper does not enhance participation in a fecal immunochemical test-based colorectal cancer screening program: randomized clinical trial
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DOI：
10.1097/cej.0b013e32835b3882
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发表时间：
2013-07-01
影响因子：
2.4
通讯作者：
Dekker, Evelien
中科院分区：
文献类型：
--
作者：
Denters, Maaike J.;Deutekom, Marije;Dekker, Evelien
对粪便样本采集的不适是参与基于粪便检测的结直肠癌筛查的常见障碍。目的是评估粪便收集纸是否能提高参与粪便免疫化学试验（FIT）为基础的结直肠癌筛查计划。随机临床试验。第二轮一年两次的荷兰FIT结直肠癌筛查项目试点。从普通人群中随机抽取10265名年龄在50-75岁之间的男性和女性，平均患结直肠癌的风险，有资格参加。受邀者被随机分配至仅FIT组（n=5136）或FIT联合粪便收集纸组（n=5129）。主要的结局指标是参与筛查。总体而言，10265个测试中返回了5367个测试（52%）。在仅使用FIT的组中，返回了2694次测试[52%; 95%置信区间（CI）：51-54%]，而在采集纸组中返回了2673次测试（52%; 95% CI：51-54%）。参与率的差异不显著（相对风险：0.99; 95%CI：0.97-1.04）。粪便收集纸不会增加基于FIT的结直肠癌筛查的参与率。未来的研究应该探索其他促进参与结直肠癌筛查计划的方法。
Discomfort with the collection of a stool sample is a frequently cited barrier for participation in fecal test-based colorectal cancer screening. The objective was to evaluate whether a feces collection paper enhances participation in a fecal immunochemical test (FIT)-based colorectal cancer screening program. Randomized clinical trial. Second round of a biannual Dutch FIT-based colorectal cancer screening program pilot. A random sample of 10 265 individuals from the general population, men and women aged 50-75 years at an average risk for colorectal cancer, was eligible for participation. Invitees were randomized to an FIT-only group (n=5136) or an FIT in combination with a feces collection paper group (n=5129). The main outcome measure was participation in screening. Overall, 5367 tests of 10 265 were returned (52%). In the FIT-only group, 2694 tests were returned [52%; 95% confidence interval (CI): 51-54%] versus 2673 tests in the collection paper group (52%; 95% CI: 51-54%). This difference in the participation rate was not significant (relative risk: 0.99; 95% CI: 0.97-1.04). A feces collection paper does not increase participation rates in FIT-based colorectal cancer screening. Future studies should explore other ways of facilitating participation in colorectal cancer screening programs.