Characterization of a calcium current in a vertebrate cholinergic presynaptic nerve terminal
Characterization of a calcium current in a vertebrate cholinergic presynaptic nerve terminal
复制标题
脊椎动物胆碱能突触前神经末梢钙电流的表征
作者：
E. Stanley;G. Goping
Calcium currents were recorded from a cholinergic presynaptic nerve terminal in the chick ciliary ganglion using the whole-cell voltage- clamp technique. The presynaptic element of this synapse is in the form of a calyx that envelops the postsynaptic ciliary neuron. A method was developed to isolate the ciliary neuron, expose the calyx, and apply patch-clamp electrodes under visual control. The presynaptic Ca current activated at +30 mV with a fast time constant of about 1.5 msec and deactivated at -80 mV with a time constant of about 0.5 msec, values that are consistent with a role in action-potential-dependent transmitter release. The calyx Ca current was blocked by 0.1 mM Cd or 2 microM omega-conotoxin and was resistant to voltage-dependent inactivation. The presynaptic Ca channel exhibits similarities to the N- type group but differs from these by the minimal voltage-dependent inactivation. This type of channel, designated CaN-PT (N-like, presynaptic terminal), may play a key role in transmitter release at many vertebrate fast-transmitting synapses.
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影响因子：
6.5
作者：
STENN, KS;LINK, R;KUKLINSKA, E
通讯作者：
KUKLINSKA, E
触动神经递质分泌的触发器：对鱿鱼巨型突触前末梢钙通道的研究。
DOI：
--
发表时间：
1989
期刊：
Society of General Physiologists series
影响因子：
--
作者：
Augustine,GJ;Buchanan,JA;Charlton,MP;Osses,LR;Smith,SJ
通讯作者：
Smith,SJ
影响因子：
56.9
作者：
MILLER, RJ
通讯作者：
MILLER, RJ
体外大鼠交感神经元多种Ca2+通道的分布。
影响因子：
3.6
作者：
Thayer,SA;Hirning,LD;Miller,RJ
通讯作者：
Miller,RJ
影响因子：
5.5
作者：
FOX, AP;NOWYCKY, MC;TSIEN, RW
通讯作者：
TSIEN, RW