Ovarian and extraovarian endometriosis-associated cancer
Ovarian and extraovarian endometriosis-associated cancer
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DOI：
10.1016/s0029-7844(02)02149-x
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发表时间：
2002-10-01
影响因子：
7.2
通讯作者：
Wolf, JK
中科院分区：
文献类型：
--
作者：
Modesitt, SC;Tortoler-Luna, G;Wolf, JK
目的：为了确定子宫内膜异位症相关的腹膜内癌妇女的临床特征，根据癌症与子宫内膜异位症的关系评估差异，并评估与生存相关的因素。D.安德森癌症中心从1970年到1999年确定了同时患有子宫内膜异位症和腹膜内癌的患者。根据癌症与子宫内膜异位症的关系以及与生存率的相关性，对人口统计学和临床病理学特征的差异进行了评估。25例子宫内膜异位症引起的卵巢癌患者，21例子宫内膜异位症引起的卵巢外癌患者，33例子宫内膜异位症和卵巢癌位于同一位置但没有明确的转移点的患者，卵巢癌合并子宫内膜异位症36例。子宫内膜异位症引起的卵巢外癌患者更可能是绝经后（P <0.001）和使用激素替代疗法（P <0.001）。中位年龄为47岁，最常见的组织学肿瘤类型为透明细胞和类透明细胞（各占23%），最常见的分期为I期（31%）。中位生存期为35个月。单因素生存分析显示，妊娠（P <0.038）、分级（P <0.001）、分期（P <0.001）、组织学（P <0.01）和化疗类型（P <0.011）与生存相关。多变量分析显示，阶段和妊娠独立预测survival.CONCLUSION：妇女与乳腺癌相关的癌症是典型的绝经前，有很高的发病率，类胶质细胞和亲爱的细胞组织学，并有早期疾病。阶段和妊娠独立预测生存。(C)2002年由美国妇产科医师学会。
OBJECTIVE: To determine clinical characteristics of women with endometriosis-associated intraperitoneal cancers, to assess differences based on the relationship of the cancer to the endometriosis, and to assess factors associated with survival.METHODS: A search of medical records at The University of Texas M. D. Anderson Cancer Center from 1970 to 1999 identified patients who had synchronous endometriosis and intraperitoneal cancer. Demographic and clinicopathologic characteristics were evaluated for differences based on the relationship of the cancer to the endometriosis and for correlation with survival.RESULTS: One hundred fifteen patients were identified: 25 patients with ovarian cancer arising in endometriosis, 21 with an extraovarian cancer arising in endometriosis, 33 patients with endometriosis and ovarian cancer in the same location but without a definite transition point, and 36 patients with ovarian cancer and incidental endometriosis. Women with extraovarian cancers arising in endometriosis were more likely to be postmenopausal (P < .001) and use hormone replacement (P < .001). The median age was 47 years, the most common histological tumor types were dear cell and endometrioid (23% each), and the most common stage was stage I (31%). The median survival was 35 months. Univariate survival analysis revealed that gravidity (P < .038), grade (P < .001), stage (P < .001), histology (P < .01), and type of chemotherapy (P < .011) correlated with survival. Multivariable analysis revealed that stage and gravidity independently predicted survival.CONCLUSION: Women with endometriosis-associated cancers are typically premenopausal, have a high incidence of endometrioid and dear cell histologies, and have early stage disease. Stage and gravidity independently predicted survival. (C) 2002 by The American College of Obstetricians and Gynecologists.