EFFECTS OF THE PLATELET-DERIVED GROWTH-FACTOR INSULIN-LIKE GROWTH FACTOR-I COMBINATION ON BONE REGENERATION AROUND TITANIUM DENTAL IMPLANTS - RESULTS OF A PILOT-STUDY IN BEAGLE DOGS
EFFECTS OF THE PLATELET-DERIVED GROWTH-FACTOR INSULIN-LIKE GROWTH FACTOR-I COMBINATION ON BONE REGENERATION AROUND TITANIUM DENTAL IMPLANTS - RESULTS OF A PILOT-STUDY IN BEAGLE DOGS
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DOI：
10.1902/jop.1991.62.11.710
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发表时间：
1991-11-01
影响因子：
4.3
通讯作者：
WILLIAMS, RC
中科院分区：
文献类型：
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作者：
LYNCH, SE;BUSER, D;WILLIAMS, RC
本研究的目的是证实在同时应用和不同时应用血小板衍生生长因子（PDGF）和胰岛素样生长因子（IGF-I）的情况下植入的压配钛种植体周围骨的早期伤口愈合事件。 在种植体植入前9个月，拔除8只比格犬的所有下颌前磨牙。 随后，将40个在顶端部分具有2个横向孔的专门制造的钛种植体压配到犬下颌骨的精确受体部位。 在植入后第7天和第21天处死犬，每个观察期获得12个PDGF-B/IGF-I处理的植入物和8个对照（安慰剂凝胶或未处理的）植入物。 分析编码的未脱钙切片：1）与新骨接触的种植体表面百分比; 2）填充新骨的种植体周围空间百分比; 3）填充新骨的种植体孔百分比。 使用方差分析确定处理组之间的显著差异。 在第7天，PDGF-B/IGF-I治疗部位的种植体周围间隙中的骨填充百分比和种植体表面与新骨接触的百分比均显著增加（两组均P < 0.01）。 在治疗部位和对照部位中，植入物孔填充< 1.5%（无显著差异）。 第21天时，PDGF-B/IGF-I治疗部位的种植体周围间隙中的骨填充百分比显著增加（P < 0.01）。 此时，在填充新骨的种植体孔百分比和与新骨接触的种植体表面百分比方面均未检测到显著差异。 然而，与安慰剂凝胶和未处理种植体的平均值相比，12个PDGF-B/IGF-I处理种植体中的10个在种植体孔内显示出更大量的新骨。 这些发现表明，PDGF-B/IGF-I组合可以刺激压配钛种植体周围的骨再生。 在该模型中，在存在较大骨缺损的区域（例如植入物周围骨髓间隙）中，效果似乎延长。
THE PURPOSE OF THIS STUDY WAS TO EVALUATE the early wound healing events of bone around press-fit titanium implants inserted with and without the concurrent application of a combination of platelet-derived growth factor (PDGF) and insulin-like growth factor (IGF-I). Nine months prior to implant placement all mandibular premolar teeth were extracted in 8 beagle dogs. Subsequently, 40 specially manufactured titanium implants with 2 transverse holes in the apical section were press fit into precise recipient sites in the dogs' mandibles. The dogs were sacrificed at 7 and 21 days following implant placement yielding 12 PDGF-B/IGF-I treated and 8 control (placebo gel or non-treated) implants for each observation period. Coded undecalcified sections were analyzed for: 1) percentage of implant surface in contact with new bone; 2) percentage of peri-implant space filled with new bone; and 3) percentage of implant hole filled with new bone. An analysis of variance was used to determine significant differences among the treatment groups. At 7 days, the percentage of bone fill in the peri-implant spaces and the percentage of implant surface in contact with new bone were both significantly increased in PDGF-B/IGF-I treated sites (P < 0.01 for both groups). There was < 1.5% fill of the implant holes in both treated and control sites (no significant differences). At 21 days the percentage of bone fill in the peri-implant spaces was significantly increased in the PDGF-B/IGF-I treated sites (P < 0.01). No significant differences were detected at this time in the percentage of implant hole filled with new bone nor in the percentage of implant surface in contact with new bone. However, 10 of the 12 PDGF-B/IGF-I treated implants exhibited a greater amount of new bone within the implant holes compared to the means of the placebo gel and non-treated implants. These findings suggest that the PDGF-B/IGF-I combination can stimulate bone regeneration around press-fit titanium implants. In this model the effect appears prolonged in areas where larger bone defects exist, such as in the peri-implant marrow spaces.