Hypertension and the risk of endometrial cancer: a systematic review and meta-analysis of case-control and cohort studies.
Hypertension and the risk of endometrial cancer: a systematic review and meta-analysis of case-control and cohort studies.
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DOI：
10.1038/srep44808
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发表时间：
2017-04-07
影响因子：
4.6
通讯作者：
Vatten LJ
中科院分区：
文献类型：
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作者：
Aune D;Sen A;Vatten LJ
在一些研究中，高血压病史与子宫内膜癌的风险增加有关，但结果并不一致。我们对病例对照和队列研究进行了系统回顾和荟萃分析，以阐明高血压与子宫内膜癌风险之间的关系。检索PubMed和Embase数据库至2016年2月27日。前瞻性和病例对照研究报告了调整后的相对风险估计和子宫内膜癌与高血压诊断相关的95%置信区间。使用随机效应模型估计总的相对风险。纳入了19项病例对照研究和6项队列研究。所有研究的总RR为1.61 (95% CI: 1.41-1.85, I2 = 86%)，病例对照研究的总RR为1.73 (95% CI: 1.45-2.06, I2 = 89%)，队列研究的总RR为1.32 （95% CI: 1.12-1.56, I2 = 47%）。与没有调整吸烟、体重指数、口服避孕药使用和胎次的研究相比，调整吸烟、体重指数、口服避孕药使用和胎次的研究中，高血压和子宫内膜癌之间的相关性较弱，但仍然显著。这项荟萃分析表明高血压患者患子宫内膜癌的风险增加，然而，需要进一步的研究，对混杂因素进行更全面的调整，以澄清这种关联。
A history of hypertension has been associated with increased risk of endometrial cancer in several studies, but the results have not been consistent. We conducted a systematic review and meta-analysis of case-control and cohort studies to clarify the association between hypertension and endometrial cancer risk. PubMed and Embase databases were searched up to 27th of February 2016. Prospective and case-control studies which reported adjusted relative risk estimates and 95% confidence intervals of endometrial cancer associated with a hypertension diagnosis were included. Summary relative risks were estimated using a random effects model. Nineteen case-control studies and 6 cohort studies were included. The summary RR was 1.61 (95% CI: 1.41–1.85, I2 = 86%) for all studies, 1.73 (95% CI: 1.45–2.06, I2 = 89%) for case-control studies and 1.32 (95% CI: 1.12–1.56, I2 = 47%) for cohort studies. The association between hypertension and endometrial cancer was weaker, but still significant, among studies with adjustment for smoking, BMI, oral contraceptive use, and parity, compared to studies without such adjustment. This meta-analysis suggest an increased risk of endometrial cancer among patients with hypertension, however, further studies with more comprehensive adjustments for confounders are warranted to clarify the association.