Quantitative magnetization transfer imaging for non-contrast enhanced detection of myocardial fibrosis
Quantitative magnetization transfer imaging for non-contrast enhanced detection of myocardial fibrosis
复制标题
定量磁化转移成像非对比增强检测心肌纤维化
DOI：
10.1002/mrm.28577
复制
发表时间：
2020
影响因子：
3.3
通讯作者：
López K
中科院分区：
文献类型：
--
作者：
López K
目的开发一种新的基于无钆模型的定量磁化传递（qMT）技术来评估与心肌纤维化相关的大分子变化。方法所提出的序列包括二维屏气双激发交错采集5个MT加权（MTw）破坏梯度回波图像，具有可变MT翻转角（FA）和非共振频率。使用双池交换模型和字典匹配来量化池大小比（PSR）和结合池T2弛豫（）。信号模型的开发和验证使用25 MTw图像上的牛血清白蛋白（BSA）的幻影和在体内的人大腿肌肉。针对单次屏气心脏qMT成像优化了具有5个MTw图像的方案。在10名健康受试者和5例心肌纤维化患者中进行了测试，并与晚期钆增强（LGE.ResultsPSR值在BSA体模的置信区间内的先前报道的值（浓度10%BSA = 5.9 ± 0.1%，15%BSA = 9.4 ± 0.2%）。PSR和大腿肌肉中的PSR也与文献（PSR = 10.9 ± 0.3%，= 6.4 ± 0.4us）一致。10例健康人左室整体PSR为4.30 ± 0.65%。在患者中，与LGE相关的区域的PSR降低（远端：4.68 ± 0.70% vs.纤维化：3.12 ± 0.78%，n= 5，P< .002）。结论首次进行了基于体内模型的心脏qMT标测，对于心肌纤维化的非造影剂增强评估具有良好的结果。
PurposeTo develop a novel gadolinium‐free model‐based quantitative magnetization transfer (qMT) technique to assess macromolecular changes associated with myocardial fibrosis.MethodsThe proposed sequence consists of a two‐dimensional breath‐held dual shot interleaved acquisition of five MT‐weighted (MTw) spoiled gradient echo images, with variable MT flip angles (FAs) and off‐resonance frequencies. A two‐pool exchange model and dictionary matching were used to quantify the pool size ratio (PSR) and bound pool T2 relaxation (). The signal model was developed and validated using 25 MTw images on a bovine serum albumin (BSA) phantom and in vivo human thigh muscle. A protocol with five MTw images was optimized for single breath‐hold cardiac qMT imaging. The proposed sequence was tested in 10 healthy subjects and 5 patients with myocardial fibrosis and compared to late gadolinium enhancement (LGE).ResultsPSR values in the BSA phantom were within the confidence interval of previously reported values (concentration 10% BSA = 5.9 ± 0.1%, 15% BSA = 9.4 ± 0.2%). PSR and in thigh muscle were also in agreement with literature (PSR = 10.9 ± 0.3%, = 6.4 ± 0.4 us). In 10 healthy subjects, global left ventricular PSR was 4.30 ± 0.65%. In patients, PSR was reduced in areas associated with LGE (remote: 4.68 ± 0.70% vs. fibrotic: 3.12 ± 0.78 %,n= 5,P< .002).ConclusionIn vivo model‐based qMT mapping of the heart was performed for the first time, with promising results for non‐contrast enhanced assessment of myocardial fibrosis.