A longitudinal study of diffusion tensor MRI in ALS
A longitudinal study of diffusion tensor MRI in ALS
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DOI：
10.1080/17482960701548139
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发表时间：
2007-01-01
影响因子：
--
通讯作者：
Simmons, Andy
中科院分区：
文献类型：
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作者：
Blain, Camilla R. V.;Williams, Victoria C.;Simmons, Andy
在这项研究中，我们研究了弥散张量成像(DTI)是否可以检测肌萎缩侧索硬化症(ALS)的进行性皮质脊髓束变性，以及弥散变量的变化是否反映了临床恶化。对23例ALS患者和25例健康志愿者进行了全脑DTI检查。患者和对照组的子组(n=12)返回进行第二次扫描。在ALS组评估了疾病严重程度的临床测量。使用感兴趣区方法测量沿皮质脊髓束的分数各向异性(FA)和平均弥散率(MD)的变化。11名ALS患者和11名对照组在两个时间点都有足够的DTI数据。在ALS患者和对照组之间，FA和MD在两个时间点上都有显著差异，但两者都没有随着时间的推移而发生显著变化，而患者的疾病严重程度的总体衡量标准随着时间的推移而增加。虽然我们证实DTI可以检测ALS患者的皮质脊髓束损害，但随着时间的推移，弥散测量没有显著变化。DTI的敏感性可以通过先进的数据分析技术来提高，尽管高的脱落率表明MRI作为ALS生物标记物的使用可能仅限于疾病的早期阶段。
In this study, we investigated whether diffusion tensor MRI (DTI) could detect progressive corticospinal tract degeneration in amyotrophic lateral sclerosis (ALS) and whether changes in diffusion variables reflected clinical deterioration. Twentythree ALS patients and 25 healthy volunteers underwent whole brain DTI. Patients and a subset (n=12) of controls returned for a second scan. Clinical measures of disease severity were assessed in the ALS group. Changes in fractional anisotropy (FA) and mean diffusivity (MD) were measured along the corticospinal tract using a region of interest approach. Adequate DTI data were available in 11 ALS patients and 11 controls at two time points. FA and MD differed significantly between ALS patients and controls at both time points, but neither changed significantly over time, while global measures of disease severity in patients increased with time. Although we confirmed that DTI detects corticospinal tract damage in ALS, there were no significant changes in diffusion measures over time. The sensitivity of DTI may be improved by advanced data analysis techniques, although the high dropout rate suggests that use of MRI as a biomarker in ALS may be restricted to earlier stages of disease.