Helicobacter pylori, anemia, and iron deficiency -: Relationships explored among Alaska Native children
Helicobacter pylori, anemia, and iron deficiency -: Relationships explored among Alaska Native children
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DOI：
10.1097/inf.0b013e31812e52cd
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发表时间：
2007-10-01
影响因子：
3.6
通讯作者：
Grummer-Strawn, Laurence M.
中科院分区：
文献类型：
--
作者：
DiGirolamo, Ann M.;Perry, Geraldine S.;Grummer-Strawn, Laurence M.
背景：为了了解贫血和缺铁的决定因素，研究人员开始研究幽门螺杆菌感染的作用。目前的研究评估了阿拉斯加原住民儿童贫血和缺铁的决定因素，包括幽门螺杆菌。方法：1999年，对86名儿童进行了一项基于人群的调查（答复率为67%），平均年龄为43.7个月（标准差= 16.8个月）。从儿童身上采集呼吸、粪便和静脉血样本，以检测贫血、缺铁、幽门螺杆菌、粪便失血和当前炎症情况。对家长的标准化访谈提供了有关人口统计、疾病以及膳食铁、铁吸收抑制剂和增强剂摄入量的信息。结果：在研究的 86 名儿童中，17.4% 患有贫血，38.6% 缺铁。该队列中 41% 的人具有幽门螺杆菌特异性 IgG 抗体，86% 的人通过尿素呼气试验 (UBT) 检测呈阳性，80% 的人通过粪便抗原检测呈阳性。在控制人口因素、当前炎症和抗生素使用的调整分析中，幽门螺杆菌抗体的存在成为贫血和缺铁的重要危险因素。相比之下，UBT或粪便抗原结果呈阳性的儿童比结果呈阴性的儿童患贫血或缺铁的可能性显着降低。结论：幽门螺杆菌的不同测量结果可能反映不同的感染阶段。幽门螺杆菌与贫血/缺铁之间的关系可能取决于测量的感染阶段，血清学测试反映了与贫血/缺铁相关的已确定的幽门螺杆菌感染，而UBT和粪便抗原结果反映了感染的早期阶段。
Background: Attempts to understand determinants of anemia and iron deficiency have led researchers to examine the role of Helicobacter pylori infection. The current study assessed determinants of anemia and iron deficiency, including H. pylori, in Alaska Native children.Methods: In 1999, a population-based survey was conducted among 86 children (67% response rate), mean age of 43.7 months (standard deviation = 16.8 months). Samples of breath, stool, and venous blood were obtained from children for measures of anemia, iron deficiency, H. pylori, fecal blood loss, and current inflammation. Standardized interviews with parents provided information on demographics, illness, and intake of dietary iron, iron-absorption inhibitors, and enhancers.Results: Of the 86 children studied, 17.4% were anemic and 38.6% were iron deficient. Forty-one percent of the cohort had H. pylori-specific IgG antibodies, 86% tested positive by the urea breath test (UBT), and 80% tested positive by the stool antigen test. Presence of H. pylori antibodies emerged as a significant risk factor for anemia and iron deficiency in adjusted analyses controlling for demographic factors, current inflammation, and antibiotic use. In contrast, children with positive UBT or stool antigen results were significantly less likely to have anemia or iron deficiency than those with negative results.Conclusions: Results from different measures of H. pylori may reflect different stages of infection. Relationships between H. pylori and anemia/iron deficiency may depend on the phase of infection measured, with serologic tests reflecting established H. pylori infection associated with anemia/iron deficiency, and UBT and stool antigen results reflecting an earlier stage of infection.