Early Changes in Plasma Amino Acid Concentrations during Aggressive Nutritional Therapy in Extremely Low Birth Weight Infants
Early Changes in Plasma Amino Acid Concentrations during Aggressive Nutritional Therapy in Extremely Low Birth Weight Infants
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DOI：
10.1016/j.jpeds.2010.09.082
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发表时间：
2011-04-01
影响因子：
5.1
通讯作者：
Liechty, Edward A.
中科院分区：
文献类型：
--
作者：
Blanco, Cynthia Liudmilla;Gong, Alice Kim;Liechty, Edward A.
目的探讨极低出生体重儿接受标准静脉补充氨基酸（standard intravenous amino acid，AA）或早期高补充氨基酸（early and high supplementation regimen，early and high AA）治疗后血浆氨基酸（amino acid，AA）浓度随时间的变化。具有标准AA浓度的婴儿从0.5 g/kg/d开始静脉注射AA，每天增加0.5 g/kg，最多3 g/kg/d。早期和高AA组的婴儿在出生后不久接受2 g/kg/d的静脉AA，并每天增加1 g/kg至4 g/kg/d。结果早期AA组和高AA组婴儿的总AA、总必需AA和总非必需AA浓度均显著高于对照组，其中必需AA和总AA浓度在第1天和第3天较高，非必需AA浓度仅在第3天有差异。标准AA和早期和高AA组之间有显着差异的所有AA浓度，除了非必需的氨基酸谷氨酸，天冬氨酸，甘氨酸，谷氨酰胺，丙氨酸，酪氨酸和条件必需的AA Cys.Conclusion婴儿谁收到早期和较高的胃肠外AA有较高的血浆AA浓度。（J Pediatr 2011; 158：543-8）。
Objective To examine the changes in plasma amino acid (AA) concentrations over time when extremely low birth weight infants are provided either a standard intravenous AA supplementation (standard AA) or an early and high supplementation regimen (early and high AA).Study design Sixty-two infants were enrolled at birth in a randomized, double-masked, prospective fashion and treated for 7 days. The infants with standard AA concentrations received intravenous AA starting at 0.5 g/kg/d and increased by 0.5 g/kg every day to a maximum of 3 g/kg/d. Infants in the early and high AA group received 2 g/kg/d of intravenous AA soon after birth and advanced by 1 g/kg every day to 4 g/kg/d. Plasma AA concentrations were determined by high-pressure liquid chromatography on days 1, 3, and 7.Results Total AA concentrations, total essential AA concentrations, and total nonessential AA concentrations were significantly higher in the infants in the early and high AA group; essential AA concentrations and total AA concentrations were higher at 1 and 3 days, and nonessential AA concentrations were different only on day 3. There were significant differences between standard AA and early and high AA groups for all AA concentrations except the nonessential AAs Glu, Asn, Gly, Gln, Ala, and Tyr and the conditionally essential AA Cys.Conclusion Infants who received early and higher parenteral AA had higher plasma AA concentrations. (J Pediatr 2011; 158:543-8).