Effects of telomerase and telomere length on epidermal stem cell behavior
Effects of telomerase and telomere length on epidermal stem cell behavior
复制标题
DOI：
10.1126/science.1115025
复制
发表时间：
2005-08-19
期刊：
影响因子：
56.9
通讯作者：
Blasco, MA
中科院分区：
文献类型：
--
作者：
Flores, I;Cayuela, ML;Blasco, MA
器官内稳态的一个关键过程是干细胞从其微环境中动员出来。我们通过对小鼠模型的分析表明，端粒长度以及端粒酶的催化成分Tert是表皮干细胞动员的关键决定因素。端粒缩短抑制干细胞从其微环境中动员出来，损害毛发生长，并导致干细胞体外增殖能力受到抑制。相反，在端粒长度没有变化的情况下Tert过表达促进干细胞动员、毛发生长以及干细胞体外增殖。端粒和端粒酶对干细胞生物学的影响预示着它们在癌症和衰老中的作用。
A key process in organ homeostasis is the mobilization of stem cells out of their niches. We show through analysis of mouse models that telomere length, as well as the catalytic component of telomerase, Tert, are critical determinants in the mobilization of epidermal stem cells. Telomere shortening inhibited mobilization of stem cells out of their niche, impaired hair growth, and resulted in suppression of stem cell proliferative capacity in vitro. In contrast, Tert overexpression in the absence of changes in telomere length promoted stem cell mobilization, hair growth, and stem cell proliferation in vitro. The effects of telomeres and telomerase on stem cell biology anticipate their role in cancer and aging.