Expanding roles of superoxide dismutases in cell regulation and cancer.
Expanding roles of superoxide dismutases in cell regulation and cancer.
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DOI：
10.1016/j.drudis.2015.10.001
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发表时间：
2016-01
影响因子：
7.4
通讯作者：
Zheng XFS
中科院分区：
文献类型：
--
作者：
Che M;Wang R;Li X;Wang HY;Zheng XFS
活性氧（Reactive oxygen species，ROS）在正常生理和疾病，特别是癌症中具有重要作用。在正常生理条件下，它们参与氧化还原反应，并作为第二信使发挥调节功能。由于异常代谢，癌细胞积累过量的ROS，因此需要强活性的抗氧化系统来防止细胞损伤。超氧化物歧化酶（SOD）是催化清除超氧化物自由基的酶。在哺乳动物中有三种不同的金属酶家族成员：SOD 1（Cu/ZnSOD），SOD 2（MnSOD）和SOD 3（ecSOD）。SOD在生长、代谢和氧化应激反应中的调节功能越来越被认识到，这对癌症的发展和生存也至关重要。越来越多的证据表明，SOD也是潜在的有用的抗癌药物靶点。本文就SOD在细胞调控中的作用及其在肿瘤生物学和治疗中的作用作一综述。
Reactive oxygen species (ROS) have important roles in normal physiology and diseases, particularly cancer. Under normal physiological conditions, they participate in redox reactions and serve as second messengers for regulatory functions. Owing to aberrant metabolism, cancer cells accumulate excessive ROS, thus requiring a robustly active antioxidant system to prevent cellular damage. Superoxide dismutases (SODs) are enzymes that catalyze the removal of superoxide free radicals. There are three distinct members of this metalloenzyme family in mammals: SOD1 (Cu/ZnSOD), SOD2 (MnSOD) and SOD3 (ecSOD). SODs are increasingly recognized for their regulatory functions in growth, metabolism and oxidative stress responses, which are also crucial for cancer development and survival. Growing evidence shows that SODs are also potentially useful anticancer drug targets. This review will focus on recent research of SODs in cellular regulation, with emphasis on their roles in cancer biology and therapy.