PSYCHOSOCIAL MODIFIERS OF IMMUNOCOMPETENCE IN MEDICAL-STUDENTS
PSYCHOSOCIAL MODIFIERS OF IMMUNOCOMPETENCE IN MEDICAL-STUDENTS
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DOI：
10.1097/00006842-198401000-00003
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发表时间：
1984-01-01
影响因子：
3.3
通讯作者：
GLASER, R
中科院分区：
文献类型：
--
作者：
KIECOLTGLASER, JK;GARNER, W;GLASER, R
研究了自然发生的应激源对免疫反应组成部分的影响。对75名一年级医学生抽取两次血液，一次是在期末考试前1个月抽取基线样本，另一次是在期末考试第一天抽取压力样本。霍姆斯-拉赫社会调整量表和加州大学洛杉矶分校孤独感量表的得分中位数为2。2同学们。2重复测量ANOVA[方差分析]与试验变量相结合。自然杀伤（NK）细胞活性从第1个样品到第2个样品明显下降。在压力生活事件和孤独感上得分高的人NK活性水平明显较低。第1 ~ 2个样本血浆总IgA显著升高，血浆IgG、IgM、c反应蛋白和唾液IgA变化不显著。
The effects of a naturally occurring stressor on components of the immune response were studied. Blood was drawn twice from 75 first-year medical students with a baseline sample taken 1 mo. before their final examinations and a stress sample drawn on the 1st day of final examinations. Median splits on scores from the Holmes-Rahe Social Readjustment Rating Scale and the UCLA [University of California at Los Angeles] Loneliness Scale produced a 2 .times. 2 .times. 2 repeated measures ANOVA [analysis of variance] when combined with the trials variable. Natural killer (NK) cell activity declined significantly from the 1st to the 2nd sample. High scorers on stressful life events and loneliness had significantly lower levels of NK activity. Total plasma IgA increased significantly from the 1st to 2nd sample, while plasma IgG and IgM, C-reactive protein and salivary IgA did not change significantly.