Cognitive Characteristics Associated with Mild Cognitive Impairment in Parkinson's Disease
Cognitive Characteristics Associated with Mild Cognitive Impairment in Parkinson's Disease
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DOI：
10.1159/000235247
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发表时间：
2009-01-01
影响因子：
2.4
通讯作者：
Roger, D.
中科院分区：
文献类型：
--
作者：
McKinlay, A.;Grace, R. C.;Roger, D.
背景：认知功能障碍在帕金森病（PD）中很常见，但其范围是可变的。本研究的目的是确定与PD相关的不同认知亚组。方法：在聚类分析中使用了广泛的神经心理学测量和认知领域，以确定患者的亚组。结果：确定了三个亚组的患者。与对照组相比，一个PD亚组显示无或极轻微的认知损害（PD-NCI），第二组显示轻度至重度认知损害（PD-UCI）的可变或不确定模式，第三组在大多数认知领域有严重认知损害的证据（轻度认知损害; PD-MCI）。这些亚组在年龄、运动障碍或疾病持续时间方面没有差异。结论：PD患者在认知表现方面是异质性的，并且有可能识别处于痴呆临床前阶段的患者。PD患者临床前痴呆（PD-MCI）的识别为了解PD认知功能下降及其进展为痴呆提供了机会。版权所有（C）2009 S. Karger AG，巴塞尔
Background: Cognitive deficits are common in Parkinson's disease (PD), but the range of deficits is variable. The aim of this study was to identify different cognitive subgroups associated with PD. Methods: A broad range of neuropsychological measures and cognitive domains were used in a cluster analysis to identify subgroups of patients. Results: Three subgroups of patients were identified. Compared to controls, one PD subgroup showed no or minimal cognitive impairment (PD-NCI), a second group showed a variable or uncertain pattern of mild to severe cognitive impairments (PD-UCI), and a third group had evidence of severe cognitive impairment across most cognitive domains (mild cognitive impairment; PD-MCI). The subgroups did not differ with regard to age, motor impairment, or disease duration. Conclusions: Patients with PD are heterogeneous with regard to cognitive presentation and it may be possible to identify patients in the preclinical stage of dementia. The identification of preclinical dementia in PD patients (PD-MCI) provides an opportunity to understand cognitive decline in PD and its progression to dementia. Copyright (C) 2009 S. Karger AG, Basel