Acetylcholine receptors containing the β2 subunit are involved in the reinforcing properties of nicotine
Acetylcholine receptors containing the β2 subunit are involved in the reinforcing properties of nicotine
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DOI：
10.1038/34413
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发表时间：
1998-01-08
期刊：
影响因子：
64.8
通讯作者：
Changeux, JP
中科院分区：
文献类型：
--
作者：
Picciotto, MR;Zoli, M;Changeux, JP
大脑中脑边缘系统中神经递质多巴胺的释放介导了包括尼古丁在内的几种滥用药物的强化特性（1）。在这里，我们研究了高亲和力神经元烟碱乙酰胆碱受体（2）对尼古丁对缺乏该受体β 2亚基的小鼠中脑边缘多巴胺系统的影响的贡献（3）。我们发现，尼古丁刺激野生型小鼠腹侧纹状体多巴胺的释放，但在β 2-突变小鼠腹侧纹状体没有。使用膜片钳记录，我们表明，中脑多巴胺能神经元从没有β 2亚基的小鼠不再响应尼古丁，尼古丁的自我管理在这些突变小鼠减弱。我们的研究结果有力地支持了含有β 2的神经元烟碱乙酰胆碱受体参与介导尼古丁的增强特性的观点。
Release of the neurotransmitter dopamine in the mesolimbic system of the brain mediates the reinforcing properties of several drugs of abuse, including nicotine(1). Here we investigate the contribution of the high-affinity neuronal nicotinic acetylcholine receptor(2) to the effects of nicotine on the mesolimbic dopamine system in mice lacking the beta 2 subunit of this receptor(3). We found that nicotine stimulates dopamine release in the ventral striatum of wild-type mice but not in the ventral striatum of beta 2-mutant mice. Using patch-clamp recording, we show that mesencephalic dopaminergic neurons from mice without the beta 2 subunit no longer respond to nicotine, and that self-administration of nicotine is attenuated in these mutant mice. Our results strongly support the idea that the beta 2-containing neuronal nicotinic acetycholine receptor is involv ed in mediating the reinforcing properties of nicotine.