Starvation promotes odor/feeding-time associations in flies
Starvation promotes odor/feeding-time associations in flies
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DOI：
10.1101/lm.045039.117
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发表时间：
2017-07-01
影响因子：
2
通讯作者：
Heisenberg, Martin
中科院分区：
文献类型：
--
作者：
Chouhan, Nitin Singh;Wolf, Reinhard;Heisenberg, Martin
饥饿导致一种激励状态，促进各种行为，如进食，行走和搜索。饥饿的果蝇可以形成气味/进食时间协会，但饥饿在编码“时间”中的作用知之甚少。在这里，我们表明，饥饿的程度与苍蝇的能力，建立气味/喂养时间的记忆。长时间的饥饿促进气味/进食时间协会后，只有一个周期的相互培训。我们还表明，饥饿是必要的收购，但气味/喂养时间记忆的检索是不必要的。最后，即使长时间饥饿，功能性昼夜节律振荡器对于建立气味/进食时间记忆也是必不可少的。
Starvation causes a motivational state that facilitates diverse behaviors such as feeding, walking, and search. Starved Drosophila can form odor/feeding-time associations but the role of starvation in encoding of "time" is poorly understood. Here we show that the extent of starvation is correlated with the fly's ability to establish odor/feeding-time memories. Prolonged starvation promotes odor/feeding-time associations after just a single cycle of reciprocal training. We also show that starvation is required for acquisition but is dispensable for retrieval of odor/feeding-time memory. Finally, even with extended starvation, a functional circadian oscillator is indispensable for establishing odor/feeding-time memories.