Association between pregnancy complications and small-for-gestational-age birth weight defined by customized fetal growth standard versus a population-based standard
Association between pregnancy complications and small-for-gestational-age birth weight defined by customized fetal growth standard versus a population-based standard
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DOI：
10.3109/14767058.2010.506566
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发表时间：
2011-03-01
影响因子：
1.8
通讯作者：
Gardosi, Jason
中科院分区：
文献类型：
--
作者：
Odibo, Anthony O.;Francis, Andre;Gardosi, Jason
方法。对超声数据库中符合纳入标准的54,433例孕妇进行了回顾性队列研究。定制百分位数的系数是使用42,277例孕妇得出的，并与从其他人群获得的系数进行了比较。定义了两个不良结局指标(在新生儿病房居住超过7天和死产[[SB]])，并使用12,456例孕妇作为验证样本，计算人口标准定义为SGA和定制标准定义为SGA的妊娠组的每个结局的风险。A欧元积分该人群在40周时以体重表示的增长潜力为3524克(标准误差：402克)。在验证人群中，使用人群和定制标准确定了4055例SGA病例。通过定制的方法额外确定为SGA的病例，每种不良结果类别的风险都显著增加。仅用定制方法检测SB高危妊娠的敏感度和特异度分别为32.7%(95%可信区间27.0~38.8%)和95.1%(95%CI：94.7~95.0%)，而单纯以人群为基础的方法检出SGA的敏感度和特异度分别为0.8%(95%CI 0.1~2.7%)和98.0%(95%CI 97.8~98.2%)。分别是。结论。由定制的生长潜力定义的欧元积分SGA能够识别出比目前使用的胎儿生长国家标准更多的有不良结局风险的妊娠。
Method. aEuro integral A retrospective cohort study of an ultrasound database using 54,433 pregnancies meeting inclusion criteria was conducted. Coefficients for customized centiles were derived using 42,277 pregnancies and compared with those obtained from other populations. Two adverse outcome indicators were defined (greater than 7 day stay in the neonatal unit and stillbirth [[SB]]), and the risk for each outcome was calculated for the groups of pregnancies defined as SGA by the population standard and SGA by the customized standard using 12,456 pregnancies for the validation sample.Results. aEuro integral The growth potential expressed as weight at 40 weeks in this population was 3524 g (standard error: 402 g). In the validation population, 4055 cases of SGA were identified using both population and customized standards. The cases additionally identified as SGA by the customized method had a significantly increased risk of each of the adverse outcome categories. The sensitivity and specificity of those identified as SGA by customized method only for detecting pregnancies at risk for SB was 32.7%% (95%% confidence interval [[CI]] 27.0--38.8%%) and 95.1%% (95%% CI: 94.7--95.0%%) versus 0.8%% (95%% CI 0.1--2.7%%) and 98.0%% (95%% CI 97.8--98.2%%)for those identified by only the population-based method, respectively.Conclusion. aEuro integral SGA defined by customized growth potential is able to identify substantially more pregnancies at a risk for adverse outcome than the currently used national standard for fetal growth.