Age-associated differences in cognitive performance in older community dwelling schizophrenia patients: Differential sensitivity of clinical neuropsychological and experimental information processing tests
Age-associated differences in cognitive performance in older community dwelling schizophrenia patients: Differential sensitivity of clinical neuropsychological and experimental information processing tests
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DOI：
10.1016/j.schres.2007.10.026
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发表时间：
2008-11-01
影响因子：
4.5
通讯作者：
Harvey, Philip D.
中科院分区：
文献类型：
--
作者：
Bowie, Christopher R.;Reichenberg, Abraham;Harvey, Philip D.
认知功能障碍是精神分裂症的一个常见特征，在精神病发作之前就存在缺陷，并且在第一次发作时为中度至重度。在第一次发作后认知功能障碍的过程中存在争议。本研究探讨了老年社区生活精神分裂症患者（n = 172）的临床神经心理（NP）和信息处理任务的年龄相关的差异。与健康对照受试者（n = 70）相比，精神分裂症患者在各年龄组的NP测试中没有差异，但在信息处理测试的更复杂组成部分中显示出与年龄相关的认知恶化的证据。精神分裂症患者认知功能中的认知障碍相关变化可能是疾病过程和感兴趣的认知测量的处理需求的函数。具有固定难度的测试，例如临床NP测试，可能在其灵敏度方面与可以执行参数难度操作的测试不同。(C)2007 Elsevier B.V.保留所有权利。
Cognitive dysfunction is a common feature of schizophrenia and deficits are present before the onset of psychosis, and are moderate to severe by the time of the first episode. Controversy exists over the course of cognitive dysfunction after the first episode. This study examined age-associated differences in performance on clinical neuropsychological (NP) and information processing tasks in a sample of geriatric community living schizophrenia patients (n = 172). Compared to healthy control subjects (n = 70), people with schizophrenia did not differ on NP tests across age groups but showed evidence for age-associated cognitive worsening on the more complex components of an information-processing test. Age-related changes in cognitive function in schizophrenia may be a function of both the course of illness and the processing demands of the cognitive measure of interest. Tests with fixed difficulty, such as clinical NP tests, may differ in their sensitivity from tests for which parametric difficulty manipulations can be performed. (C) 2007 Elsevier B.V. All rights reserved.