Cobalt-Tertiary-Amine-Mediated Hydroxytrifluoromethylation of Alkenes with CF3Br and Atmospheric Oxygen
Cobalt-Tertiary-Amine-Mediated Hydroxytrifluoromethylation of Alkenes with CF3Br and Atmospheric Oxygen
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DOI：
10.1021/acscatal.0c00498
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发表时间：
2020-04-03
期刊：
影响因子：
12.9
通讯作者：
Li, Suhua
中科院分区：
文献类型：
--
作者：
Li, Qankun;Fan, Wu;Li, Suhua
介绍了在钴叔胺的介导下，烯烃与溴三氟甲烷（CF3Br）和大气氧的温和、高效的羟基三氟甲基化反应。该反应具有广泛的底物范围和良好的官能团相容性。机理研究表明，该反应是通过自由基途径进行的，该途径是通过先前未开发的高效n-异丙基- n，2-二甲基丙烷-2-胺与Co（II）结合，使CF3Br单电子还原为CF3自由基。
The mild and efficient hydroxytrifluoromethylation of alkenes with bromotrifluoromethane (CF3Br) and atmospheric oxygen mediated by cobalt-tertiary amine is described. This reaction proceeds with broad substrate scope and good functional group compatibility. Mechanistic studies indicate that the reaction proceeds through a radical pathway, which is enabled by combination of the previously unexplored highly efficient N-isopropyl-N,2-dimethylpropan-2-amine with Co(II) for the single electron reduction of CF3Br to CF3 radical.