Absolute Stereochemistry of the Squalene Synthase Inhibitor Zaragozic Acid C
Absolute Stereochemistry of the Squalene Synthase Inhibitor Zaragozic Acid C
复制标题
角鲨烯合酶抑制剂 Zaragozic Acid C 的绝对立体化学
DOI：
10.1021/jo00087a054
复制
发表时间：
1994
影响因子：
3.6
通讯作者：
G. D. Berger
中科院分区：
文献类型：
--
作者：
C. Santini;R. Ball;G. D. Berger
萨拉戈萨酸是一组结构相关的真菌代谢产物，是角鲨烯合酶的强效抑制剂。角鲨烯合酶催化代谢途径中的第一个生化转化，其致力于胆固醇的产生。[1]阻断这种酶作为降低升高的血清胆固醇的方法的兴趣导致了两个研究小组独立地发现了这些抑制剂。2在这些实验室之前的报告中，萨拉戈萨酸的化学连接性已经得到阐明。3
The zaragozic acids are a group of structurally related fungal metabolites which are powerful inhibitors of the enzyme squalene synthase. Squalene synthase catalyses the first biochemical transformation in the metabolic pathway which is committed to the production of cholesterol. 1 The interest in blocking this enzyme as a method of lowering elevated serum cholesterol has led to the independent discovery of these inhibitors bytwo groups. 2 In previous reports from these laboratories, the chemical connectivities of the zaragozic acids have been elucidated. 3