Gender-dependent alterations in serum leptin in alcoholic cirrhosis.
Gender-dependent alterations in serum leptin in alcoholic cirrhosis.
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DOI：
10.1016/s0016-5085(98)70267-7
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发表时间：
1998-10
期刊：
影响因子：
29.4
通讯作者：
A. McCullough;E. Bugianesi;G. Marchesini;S. Kalhan
中科院分区：
文献类型：
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作者：
A. McCullough;E. Bugianesi;G. Marchesini;S. Kalhan
背景与目的睡眠素是一种减少食物摄入和增加能量消耗的肽。它在脂肪细胞中产生，受到细胞因子的刺激，在女性血清中的水平更高。由于厌食症、高代谢和细胞因子水平升高在肝硬化中经常被观察到，我们假设血清瘦素水平在肝硬化中会升高。本研究的目的是探讨血清瘦素与性别、身体组成和肿瘤坏死因子（TNF）的关系。方法研究男性（n = 18）和女性（n = 10）戒酒性酒精性肝硬化患者，并与对照组（男性15例，女性8例）进行比较。采用H2[18O]和溴化物稀释法计算脂肪质量、无脂体质量和体细胞质量。免疫法测定血清瘦素和肿瘤坏死因子浓度。结果只有男性肝硬化患者的脂肪质量降低（P < 0.05），而男性和女性肝硬化患者的体细胞质量均降低（P < 0.01）。与对照组相比，女性肝硬化患者的瘦素水平升高（P < 0.001），而男性肝硬化患者的瘦素水平没有升高。当每公斤脂肪量表示瘦素时，男性肝硬化患者（P < 0.01）和女性肝硬化患者（P < 0.01）的瘦素水平均升高。肝硬化组和对照组的女性瘦素水平都高于男性。TNF在男性和女性肝硬化患者中均升高，且与瘦素水平无关。结论肝硬化患者血清瘦素水平升高，这与身体成分的性别和性别依赖性改变有关。胃肠病学1998;115:947 - 953
Background & AimsLeptin is a peptide that decreases food intake and increases energy expenditure. It is produced in fat cells, is stimulated by cytokines, and its levels in serum are higher in females. Because anorexia, hypermetabolism, and elevated cytokine levels are frequently observed in cirrhosis, we hypothesized that the serum leptin level would be elevated in cirrhosis. The aim of this study was to investigate the relationship of serum leptin to gender, body composition, and tumor necrosis factor (TNF).MethodsMale (n = 18) and female (n = 10) abstinent alcoholic cirrhotic patients were studied and compared with control subjects (15 male and 8 female). Fat mass, fat-free body mass, and body cell mass were calculated by using H2[18O] and bromide dilution methodology. Serum leptin and TNF concentrations were measured by immunoassays.ResultsFat mass was decreased only in male cirrhotics (P < 0.05), whereas body cell mass was decreased in both male and female cirrhotics (P < 0.01). Leptin levels were elevated in female (P < 0.001) but not male cirrhotics compared with controls. When expressed per kilogram of fat mass, leptin was elevated in both male (P < 0.01) and female (P < 0.01) cirrhotics. Women in both cirrhotic and control groups had higher leptin levels than men. TNF was elevated in both male and female cirrhotics and did not correlate with leptin levels.ConclusionsCirrhotics have elevated serum leptin levels, which are related to both gender- and gender-dependent alterations in body composition. GASTROENTEROLOGY 1998;115:947-953