Operant conditioning of reciprocal inhibition in rat soleus muscle
Operant conditioning of reciprocal inhibition in rat soleus muscle
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DOI：
10.1152/jn.00253.2006
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发表时间：
2006-10-01
影响因子：
2.5
通讯作者：
Wolpaw, Jonathan R.
中科院分区：
文献类型：
--
作者：
Chen, Xiang Yang;Chen, Lu;Wolpaw, Jonathan R.
大鼠比目鱼肌相互抑制的操作性条件反射。J Neurophysiol 96：2144-2150，2006.首次发表于2006年6月28日; doi：10.1152/jn.00253.2006。脊髓牵张反射（SSR）的电模拟物H反射的操作性条件反射诱导脊髓中的活动依赖性可塑性，并且可用于改善脊髓损伤后的运动。为了进一步评估脊髓反射条件反射的潜在临床意义，本研究询问另一个定义明确的脊髓反射通路，相互抑制（RI）的基础上的双突触通路，是否也可以操作条件反射。将肌电图（EMG）电极植入Sprague-Dawley大鼠的右比目鱼肌（SOL）和胫骨前肌（TA），并在腓总神经（CP）上植入刺激袖带。当背景肌电图在两块肌肉保持在规定的范围内，CP刺激引起TA H反射和SOL RI。在收集20天的对照数据后，将每只大鼠暴露于向上调节（RIup模式）或向下调节（RIdown模式）50天，其中如果由CP刺激诱发的SOL RI大于（RIup模式）或小于（RIdown模式）标准，则发生食物奖励。TA和SOL背景EMG和TA M反应保持稳定。在每只大鼠中，RI条件化是成功的（即，在正确的方向上改变>= 20%）。在RIup大鼠中，最终SOL RI平均为对照组的171 +/- 28%（平均值+/- SE），最终TA H反射平均为114 +/-14%。在RI下降大鼠中，最终SOL RI平均为对照组的37 +/- 13%，最终TA H反射平均为60 +/-18%。最终SOL RI和TA H反射大小显著相关。因此，就像SSR和H反射一样，RI也可以被操作性地条件反射;条件反射也可以影响另一个反射。
Operant conditioning of reciprocal inhibition in rat soleus muscle. J Neurophysiol 96: 2144-2150, 2006. First published June 28, 2006; doi:10.1152/jn.00253.2006. Operant conditioning of the H-reflex, the electrical analog of the spinal stretch reflex (SSR), induces activity-dependent plasticity in the spinal cord and might be used to improve locomotion after spinal cord injury. To further assess the potential clinical significance of spinal reflex conditioning, this study asks whether another well-defined spinal reflex pathway, the disynaptic pathway underlying reciprocal inhibition (RI), can also be operantly conditioned. Sprague-Dawley rats were implanted with electromyographic (EMG) electrodes in right soleus (SOL) and tibialis anterior (TA) muscles and a stimulating cuff on the common peroneal (CP) nerve. When background EMG in both muscles remained in defined ranges, CP stimulation elicited the TA H-reflex and SOL RI. After collection of control data for 20 days, each rat was exposed for 50 days to up-conditioning (RIup mode) or down-conditioning (RIdown mode) in which food reward occurred if SOL RI evoked by CP stimulation was more (RIup mode) or less (RIdown mode) than a criterion. TA and SOL background EMG and TA M response remained stable. In every rat, RI conditioning was successful (i.e., change >= 20% in the correct direction). In the RIup rats, final SOL RI averaged 171 +/- 28% (mean +/- SE) of control, and final TA H-reflex averaged 114 +/- 14%. In the RIdown rats, final SOL RI averaged 37 +/- 13% of control, and final TA H-reflex averaged 60 +/- 18%. Final SOL RI and TA H-reflex sizes were significantly correlated. Thus like the SSR and the H-reflex, RI can be operantly conditioned; and conditioning one reflex can affect another reflex as well.