Hippocampal denervation causes rapid forgetting of olfactory information in rats.
Hippocampal denervation causes rapid forgetting of olfactory information in rats.
复制标题
海马去神经导致大鼠快速忘记嗅觉信息。
DOI：
--
复制
发表时间：
1984
影响因子：
11.1
通讯作者：
G. Lynch
中科院分区：
文献类型：
--
作者：
U. Stäubli;G. Ivy;G. Lynch
在改良的径向迷宫中，对老鼠进行一系列的两种气味辨别训练，以获取水奖励。每天使用不同的气味对。经过三到四对之后，老鼠只需 3-5 次试验就能学会选择正确的气味。然后，动物的外侧内嗅皮质（受外侧嗅束支配）或背侧内嗅皮质（不是嗅觉系统的目标）受到电解损伤。如果试验之间间隔较短（30 秒至 2 分钟），则第一类损伤不会影响表现。然而，当试验间隔 3-10 分钟时，大鼠会受到严重损害。无论延迟时间长短，背侧病变对嗅觉辨别力没有影响。在另外的实验中，老鼠接受了 10 次试验的训练，试验间隔很短，然后 1 小时后进行测试，线索的重要性颠倒了。背部损伤的动物继续对以前正确的气味做出反应，而侧内嗅损伤的动物则立即改变其反应选择。这些结果提供的证据表明，海马系统损伤在大鼠中产生的快速遗忘综合征与报道的颞叶损伤或功能障碍的人类相似。
Rats were trained on a succession of two-odor discriminations for a water reward in a modified radial maze. A different odor pair was used each day. After three or four pairs, rats would learn to choose the correct odor in only 3-5 trials. Animals were then subjected to electrolytic lesions in the lateral entorhinal cortex, which is innervated by the lateral olfactory tract, or in the dorsal entorhinal cortex, which is not a target of the olfactory system. Lesions of the first type did not interfere with performance, provided a short interval (30 sec to 2 min) was used between trials. However, the rats were severely impaired when trials were separated by 3-10 min. Dorsal lesions had no effect on olfactory discrimination irrespective of length of delay. In additional experiments, the rats were trained for 10 trials with short inter-trial intervals and then tested 1 hr later with the significance of the cues reversed. Animals with dorsal lesions continued to respond to the formerly correct odor while those with lateral entorhinal damage immediately reversed their response choices. These results provide evidence that lesions to the hippocampal system produce a rapid forgetting syndrome in rats comparable with that reported for humans with temporal lobe damage or dysfunction.