Estrogen metabolites for the diagnosis of schistosomiasis associated urinary bladder cancer.
Estrogen metabolites for the diagnosis of schistosomiasis associated urinary bladder cancer.
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DOI：
10.36876/smtmj.1004
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发表时间：
2016-02
期刊：
影响因子：
--
通讯作者：
M. Botelho;H. Alves;J. Richter
中科院分区：
文献类型：
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作者：
M. Botelho;H. Alves;J. Richter
在最近一期的《癌症快报》中，Gouveia和他的同事研究了一系列40名被诊断为泌尿生殖系统血吸虫病(UGS)的安哥拉患者。他们报告说，其中45%的患者出现了UGS相关的鳞状细胞癌(SCC)和/或尿路上皮细胞癌[1]。此外，这些作者进行了液-质联用分析，发现了许多雌激素样的代谢物。这些与血吸虫感染相关的代谢物包括儿茶酚雌激素醌(CEQ)和CEQ-DNA加合物，其中两种已在血吸虫中鉴定[1，2，3]。他们的结论表明，这些代谢物有望为UGS诱导的膀胱癌的致癌机理提供更深入的见解，并作为这种被忽视的热带疾病相关癌症的诊断和/或预后的生物标记物。
In a recent issue of Cancer Letters Gouveia and colleagues [1] studied a series of 40 Angolan patients diagnosed with urogenital schistosomiasis (UGS). They reported that 45% of them presented UGS-associated squamous cell carcinoma (SCC) and/or urothelial cell carcinoma [1]. In addition these authors performed Liquid Chromatography-mass spectrometry and this analysis revealed numerous estrogen like metabolites. These schistosome infection-associated metabolites included catechol estrogen quinones (CEQ) and CEQ-DNA-adducts, two of which had been identified previously in S. haematobium [1,2,3]. They conclude suggesting that these metabolites can be expected to provide deeper insights into the carcinogenesis UGS-induced bladder cancer, and as biomarkers for diagnosis and/or prognosis of this neglected tropical disease-linked cancer.