GLUCOCORTICOID AND ANTIMINERALOCORTICOID EFFECTS ON HUMAN SLEEP - A ROLE OF CENTRAL CORTICOSTEROID RECEPTORS
GLUCOCORTICOID AND ANTIMINERALOCORTICOID EFFECTS ON HUMAN SLEEP - A ROLE OF CENTRAL CORTICOSTEROID RECEPTORS
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DOI：
10.1152/ajpendo.1991.260.2.e183
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发表时间：
1991-02-01
影响因子：
--
通讯作者：
FEHM, HL
中科院分区：
文献类型：
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作者：
BORN, J;DEKLOET, ER;FEHM, HL
皮质醇调节人类的大脑功能。这种主要的内源性糖皮质激素会减少快速眼动（REM）睡眠，增加慢波睡眠（SWS）。由于皮质醇通过矿物皮质激素受体（MR）和糖皮质激素受体（GR）对大脑功能产生影响，我们对哪种类型的皮质激素受体介导这些类固醇对睡眠的影响感兴趣。健康男性在两个双盲实验中接受了测试。在实验1 （n = 8）中，受试者在四个晚上进行睡眠测试：1)在使用地塞米松（地塞米松，4 mg/天）预处理4或6天后，以及在实验夜间额外注射安慰剂或皮质醇（10 mg/h）后，2)在使用安慰剂预处理4或6天后，以及在实验夜间注射安慰剂或皮质醇（10 mg/h）后。在实验II中，受试者（n = 10）在实验夜前0800和1700小时静脉注射canrenate钾（200 mg）或安慰剂后入睡。皮质醇输注可适度提高SWS百分比（P < 0.05），显著降低REM睡眠（P < 0.01）；皮质醇对SWS的影响不依赖于Dex预处理。右美托咪定降低了SWS和REM睡眠（P < 0.05）。Canrenoate显著降低了SWS (P < 0.01)，但不影响REM睡眠。结果表明，皮质类固醇诱导的SWS变化是通过mr样中枢受体介导的，而REM睡眠的变化涉及GR。
Cortisol modulates brain functions in humans. This principal endogenous glucocorticoid in humans decreases rapid-eye-movement (REM) sleep and increases slow-wave sleep (SWS). Because cortisol exerts its effect on brain functions via mineralocorticoid receptors (MR) and glucocorticoid receptors (GR), we were interested in which type of corticosteroid receptor mediates these steroid effects on sleep. Healthy men were tested in two double-blind experiments. In experiment I (n = 8), the subject's sleep was tested during four nights: 1) after pretreatment with dexamethasone (Dex, 4 mg/day) for 4 or 6 days and after additional infusion of placebo or cortisol (10 mg/h) during the experimental night, 2) after pretreatment with placebo for 4 or 6 days and after infusion of placebo or cortisol (10 mg/h) during the experimental night. In experiment II, subjects (n = 10) slept after intravenous administration of potassium canrenoate (200 mg, at 0800 and 1700 h before experimental nights) or placebo. Cortisol infusion moderately increased the percentage of SWS (P < 0.05) and markedly decreased REM sleep (P < 0.01); influence of cortisol on SWS did not depend on pretreatment with Dex. Dex reduced both SWS and REM sleep (P < 0.05). Canrenoate markedly diminished SWS (P < 0.01) but left REM sleep unaffected. The results suggest that corticosteroid-induced changes in SWS are mediated via MR-like central receptors in humans, whereas changes in REM sleep involve GR.