Eyeblink classical conditioning to auditory and olfactory stimuli: performance among older adults with and without the apolipoprotein E epsilon 4 allele.
Eyeblink classical conditioning to auditory and olfactory stimuli: performance among older adults with and without the apolipoprotein E epsilon 4 allele.
复制标题
对听觉和嗅觉刺激的眨眼经典条件反射：有或没有载脂蛋白 E epsilon 4 等位基因的老年人的表现。
DOI：
10.1037/0894-4105.19.4.437
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发表时间：
2005
期刊：
影响因子：
2.4
通讯作者：
Murphy,Claire
中科院分区：
文献类型：
--
作者：
Moore,AnnaBacon;Bondi,MarkW;Salmon,DavidP;Murphy,Claire
阿尔茨海默病（AD）患者在眨眼经典条件反射范式（EBCC）中表现出条件反应（CR）的缓慢获得，尽管尚不清楚CR获得在疾病过程中多早受到影响。本研究调查了在发生AD的遗传风险较大的非痴呆老年人（即载脂蛋白E [APOE] ε4等位基因携带者）中，CR获得率的变化是否明显。ε4+和ε4−参与者都表现出对听觉和嗅觉CS的CR获取;然而，ε4+参与者对嗅觉CS的获取速度明显较慢。两组以相同的速率获得听觉CS的CR。结果支持嗅觉妥协在AD疾病过程的最早阶段。
Patients with Alzheimer's disease (AD) demonstrate slowed acquisition of the conditioned response (CR) in eyeblink classical conditioning paradigms (EBCC), although it is unknown how early in the course of the disease CR acquisition is affected. This study investigated whether changes in the rate of CR acquisition were apparent in nondemented older adults at greater genetic risk for developing AD (ie, carriers of the apolipoprotein E [APOE] ε4 allele). Both ε4+ and ε4− participants demonstrated CR acquisition to auditory and olfactory CSs; however, rate of acquisition to the olfactory CS was significantly slower in ε4+ persons. Both groups acquired the CR to an auditory CS at the same rate. Results support olfactory compromise in the earliest stages of the AD disease process.