Preparation, characterization, and in vitro release investigation of lutein/zein nanoparticles via solution enhanced dispersion by supercritical fluids
Preparation, characterization, and in vitro release investigation of lutein/zein nanoparticles via solution enhanced dispersion by supercritical fluids
复制标题
通过超临界流体溶液增强分散制备叶黄素/玉米醇溶蛋白纳米粒子的制备、表征和体外释放研究
DOI：
10.1016/j.jfoodeng.2011.10.025
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发表时间：
2012-04-01
影响因子：
5.5
通讯作者：
Zhao, Yaping
中科院分区：
文献类型：
--
作者：
Hu, Daode;Lin, Changchun;Zhao, Yaping
采用超临界流体溶液增强分散法（SEDS）制备叶黄素/玉米醇溶蛋白纳米颗粒。的形态，载药量，包封率，和平均粒径的纳米粒子的工艺变量的影响进行了研究。结果表明，采用SEDS工艺制备的纳米粒载药量高，包封率高。温度、压力、叶黄素/玉米醇溶蛋白比和溶液流速可以影响叶黄素/玉米醇溶蛋白纳米粒的形态、载药量、包封率和平均粒径。较低的温度和溶液流速与高压相结合，有利于更小和更规则的球体。测试样品的初始和总体药物释放行为。在45 ℃/10 MPa下处理的纳米颗粒中几乎没有观察到初始突释。叶黄素的释放曲线呈近零级释放，说明纳米粒对叶黄素的释放有一定的控制作用。(C)2011爱思唯尔有限公司版权所有。
Solution enhanced dispersion by supercritical fluids (SEDS) was applied for the production of lutein/zein nanoparticles. The effects of the process variables on the morphology, drug loading, entrapment efficiency, and mean particle size of the nanoparticles were investigated. The results showed that the nanoparticles with high drug loading and high entrapment efficiency were prepared by SEDS process. Temperature, pressure, ratio of lutein/zein, and solution flow rate can influence the morphology, drug loading, entrapment efficiency, and the mean particle size of the lutein/zein nanoparticles. The lower temperature and solution flow rate coupled with high pressure, favor smaller and more regular spheres. The initial and overall drug release behavior of the samples was tested. The initial burst release was hardly observed in the nanoparticles processed at 45 degrees C/10 MPa. Furthermore, lutein release profile displayed a near zero-order release, which implied that the nanoparticles played a role in controlled release of lutein. (C) 2011 Elsevier Ltd. All rights reserved.