Release of acetylcholine at voluntary motor nerve endings
Release of acetylcholine at voluntary motor nerve endings
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DOI：
10.1113/jphysiol.1936.sp003371
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发表时间：
1936-05-01
影响因子：
5.5
通讯作者：
Vogt, M
中科院分区：
文献类型：
--
作者：
Dale, HH;Feldberg, W;Vogt, M
对灌注的随意肌的运动神经纤维的刺激引起静脉液中乙酰胆碱的出现。直接刺激正常肌肉也有类似的效果，但当肌肉完全失去神经支配时，乙酰胆碱就不会出现。刺激运动神经会导致肌肉中乙酰胆碱的释放。当从运动神经纤维到灌注肌肉的传导在重复刺激后因疲劳而失败时，乙酰胆碱不再通过刺激神经或肌肉而释放。
Stimulation of the motor nerve fibers to perfused voluntary muscle causes the appearance of acetylcholine in the venous fluid. Direct stimulation of a normal muscle has a similar effect, but no acetylcholine appears when a muscle is completely denervated. Stimulation of the motor nerve causes a release of acetylcholine in a curarized muscle. When conduction from motor nerve fibers to perfused muscle fails from exhaustion after repeated stimulation, acetylcholine is no longer released by stimulation of either nerve or muscle.