Insulin-like growth factor I, insulin-like growth factor binding proteins, and growth hormone binding protein in Spanish premature and full-term newborns.
Insulin-like growth factor I, insulin-like growth factor binding proteins, and growth hormone binding protein in Spanish premature and full-term newborns.
复制标题
西班牙早产儿和足月新生儿的胰岛素样生长因子 I、胰岛素样生长因子结合蛋白和生长激素结合蛋白。
作者：
V. Barrios;J. Argente;J. Pozo;F. Hervás;M. Muñoz;J. Sánchez;M. Hernández
胰岛素样生长因子I （IGF-I）、igf结合蛋白1和3 （IGFBP-1和IGFBP-3）以及高亲和力生长激素结合蛋白（GHBP）的正常值在大量健康足月新生儿中尚未得到很好的确定。我们报告了271例妊娠37 - 42周出生的西班牙正常足月新生儿的IGF-I、IGFBP-I、IGFBP-3和GHBP的标准数据，并将这些结果与39例早产儿的相同参数进行了比较。此外，我们报告了在正常足月新生儿和252名健康青春期前（Tanner期I）西班牙儿童中发现的结果之间的关系。血清GHBP、IGF-I和IGFBP-3水平在早产儿中非常低，在足月新生儿中显著升高，并在儿童期继续下降（p < 0.001；方差分析）。观察到GHBP、IGF-I和IGFBP-3与胎龄呈正相关。相反，我们发现igfbp - 1与胎龄呈负相关。ponderal指数与IGF-I和IGFBP-3有直接关系。将早产新生儿组分为孕前32周和孕后32周，发现孕龄越高组IGF-I和IGFBP-3水平越高（Student's test分别p < 0.01和p < 0.05）；然而，该组IGFBP-I水平较低（经学生t检验p < 0.001），血清GHBP浓度无差异。早产儿中igfbp的存在表明它们是胎儿生长发育过程中igf - 1作用的重要调节剂。
The normal values of insulin-like growth factor I (IGF-I), IGF-binding proteins 1 and 3 (IGFBP-1 and IGFBP-3), and the high-affinity growth hormone binding protein (GHBP) are not well established in large series of healthy fullterm newborns. We report the normative data for IGF-I, IGFBP-I, IGFBP-3, and GHBP in 271 normal Spanish full-term newborns, born between 37 and 42 weeks of gestation, and compare these results with the same parameters studied in 39 premature infants. Furthermore, we report the relationship between results found in the normal full-term newborns and those of 252 healthy prepubertal (Tanner stage I) Spanish children. Serum GHBP, IGF-I, and IGFBP-3 levels are very low in the premature infant and show a significant increase in full-term newborns, and continue to decline during childhood (p < 0.001; analysis of variance). A positive correlation between GHBP, IGF-I, and IGFBP-3 versus gestational age was observed. In contrast, we found a negative correlation between IGFBP-I and gestational age. There is a direct relationship between the ponderal index and IGF-I and IGFBP-3. When the group of premature newborns was divided into infants born before or after 32 weeks of gestation, we found higher levels of IGF-I and IGFBP-3 (p < 0.01 and p < 0.05, respectively, by Student's test) in the group with the higher gestational age; however, the IGFBP-I level was lower in this group (p < 0.001 by Student's t test), with no differences seen in serum GHBP concentrations. The presence of IGFBPs in the premature infant suggests that they are important modulators of IGF-I action during fetal growth and development.