Predictors of prolonged survival after allogeneic hematopoietic stem cell transplantation for multiple myeloma.
Predictors of prolonged survival after allogeneic hematopoietic stem cell transplantation for multiple myeloma.
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DOI：
10.1002/ajh.22273
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发表时间：
2012-03
影响因子：
12.8
通讯作者：
Qazilbash, Muzaffar H.
中科院分区：
文献类型：
--
作者：
Bashir, Qaiser;Khan, Hassan;Orlowski, Robert Z.;Amjad, Ali Imran;Shah, Nina;Parmar, Simrit;Wei, Wei;Rondon, Gabriela;Weber, Donna M.;Wang, Michael;Thomas, Sheeba K.;Shah, Jatin J.;Qureshi, Sofia R.;Dinh, Yvonne T.;Popat, Uday;Anderlini, Paolo;Hosing, Chitra;Giralt, Sergio;Champlin, Richard E.;Qazilbash, Muzaffar H.
A total of 149 patients with multiple myeloma (MM) who received allogeneic hematopoietic stem cell transplantation (allo-HCT) with myeloablative (MAC; n=38) or reduced-intensity conditioning (RIC; n=110) regimens at MD Anderson Cancer Center were evaluated. Of the total, 120 (81%) patients had relapsed or had refractory disease. Median age of MM patients was 50 (28-70) years with a follow-up time of 28.5(3-164) months. The 100-day and 5-year treatment related mortality (TRM) rates were 17% and 47%, respectively. TRM was significantly lower with RIC regimens (13%) vs. 29% for MAC at 100 days (p=0.012). The cumulative incidence of grade II-IV acute graft-versus-host disease (GVHD) was 35% and chronic GVHD was 46%. PFS and OS at 5 years were 15% and 21%, respectively. In multivariate analysis, allo-HCT for primary remission consolidation was associated with longer PFS (HR 0.35; 95% CI, 0.18–0.67) and OS (HR 0.29; 95% CI 0.15–0.55), while absence of high-risk cytogenetics was associated with longer PFS only (HR 0.59; 95% CI 0.37–0.95). We observe that TRM has decreased with the use of RIC regimens and long-term disease control can be expected in a subset of MM patients undergoing allo-HCT. Further studies should be conducted in carefully designed clinical trials in this patient population.
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影响因子：
20.3
作者：
Crawley, Charles;Iacobelli, Simona;Gahrton, Gosta
通讯作者：
Gahrton, Gosta
影响因子：
4.3
作者：
Kröger, N;Perez-Simon, JA;Zander, AR
通讯作者：
Zander, AR
影响因子：
4.3
作者：
Efebera, Yvonne A.;Qureshi, Sofia R.;Cole, Suzanne M.;Saliba, Rima;Pelosini, Matteo;Patel, Ronak M.;Koca, Ebru;Mendoza, Floralyn L.;Wang, Michael;Shah, Jatin;Alousi, Amin;Hosing, Chitra;Popat, Uday;Kebriaei, Partow;Anderlini, Paolo;Khouri, Issa F.;Champlin, Richard;Giralt, Sergio;Qazilbash, Muzaffar H.
通讯作者：
Qazilbash, Muzaffar H.
影响因子：
45.3
作者：
Barlogie, B;Kyle, RA;Crowley, JC
通讯作者：
Crowley, JC
影响因子：
45.3
作者：
Bjorkstrand, Bo;Iacobelli, Simona;Gahrton, Gosta
通讯作者：
Gahrton, Gosta