Development of biomedical porous titanium filled with medical polymer by in-situ polymerization of monomer solution infiltrated into pores
Development of biomedical porous titanium filled with medical polymer by in-situ polymerization of monomer solution infiltrated into pores
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DOI：
10.1016/j.jmbbm.2009.03.003
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发表时间：
2010-01-01
影响因子：
3.9
通讯作者：
Shindoh, Taku
中科院分区：
文献类型：
--
作者：
Nakai, Masaaki;Niinomi, Mitsuo;Shindoh, Taku
通过控制多孔性，多孔金属材料可以具有低的杨氏模量，其近似等于人骨的杨氏模量。另一方面，某些医用聚合物表现出金属材料中不固有的生物功能。因此，由这些材料组成的复合材料预计将具有生物医学应用的这两个优点。然而，在使用多孔金属材料的情况下，机械性能的劣化应关注，因为应力集中可能会引起附近的pores.In本研究中，上述复合材料的制造，一个通用的过程中填充到多孔金属材料的医用聚合物已开发使用多孔纯钛（pTi）和聚甲基丙烯酸甲酯（PMMA）。在此基础上，研究了PMMA填充pTi复合材料的拉伸强度和杨氏模量（pTi/PMMA），PMMA的加入可以提高pTi的拉伸强度，特别是，在PMMA填充之前使用硅烷偶联剂预处理的pTi的拉伸强度的改善大于未使用硅烷偶联剂预处理的pTi的拉伸强度的改善。预处理的pTi，因为孔附近的应力集中可以通过钛颗粒和PMMA之间的界面张力的改善而降低。而PMMA填充对pTi弹性模量的影响小于对拉伸强度的影响，因为PMMA的弹性模量远低于pTi。此外，在一些pTi/PMMA样品的情况下，成功获得了与人骨的拉伸强度和杨氏模量相当的拉伸强度和杨氏模量。(C)2009爱思唯尔有限公司版权所有。
Porous metallic materials can have a low Young's modulus, which is approximately equal to that of human bone, by controlling the porosity. On the other hand, certain medical polymers exhibit biofunctionalities that are not intrinsically present in metallic materials. Therefore, a composite consisting of these materials is expected to possess both these advantages for biomedical applications. However, in the case of using porous metallic materials, the deterioration of mechanical properties should of concern because a stress concentration may be induced near the pores.In this study, for the fabrication of the abovementioned composite, a versatile process for filling a medical polymer into a porous metallic material has been developed using porous pure titanium (pTi) and polymethylmethacrylate (PMMA). Then, the tensile strength and Young's modulus of pTi filled with PMMA (pTi/PMMA) fabricated using this process are systematically investigated.The tensile strength of pTi can be improved by the PMMA filling, Particularly, the improvement in the tensile strength of pTi pretreated using a silane coupling agent before PMMA filling is greater than that of the non-pretreated pTi because the stress concentration near the pores may be reduced by the improvement in the interfacial adhesiveness between the titanium particles and the PMMA. in contrast, the effect of the PMMA filling on the Young's modulus of pTi is smaller than that on the tensile strength because the Young's modulus of PMMA is considerably lower than that of pTi. Further, tensile strengths and Young's moduli comparable to the tensile strength and Young's modulus of the human bone are successfully obtained in the case of some pTi/PMMA samples. (C) 2009 Elsevier Ltd. All rights reserved.