DOPAMINE AND NOREPINEPHRINE TURNOVER IN VARIOUS REGIONS OF THE RAT-BRAIN AFTER CHRONIC MANGANESE CHLORIDE ADMINISTRATION
DOPAMINE AND NOREPINEPHRINE TURNOVER IN VARIOUS REGIONS OF THE RAT-BRAIN AFTER CHRONIC MANGANESE CHLORIDE ADMINISTRATION
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DOI：
10.1016/0300-483x(82)90055-5
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发表时间：
1982-01-01
期刊：
影响因子：
4.5
通讯作者：
BRALET, J
中科院分区：
文献类型：
--
作者：
AUTISSIER, N;ROCHETTE, L;BRALET, J
用MnCl 2·4 H2O（1 mg/100 g/天，i. p.）4个月。在几个脑区域（脑干、下丘脑、纹状体和脑的其余部分）中，通过在用α-去甲肾上腺素（NE）抑制酪氨酸羟化酶后内源性DA和NE的衰减来测量多巴胺（DA）和去甲肾上腺素（NE）的周转。甲基对酪氨酸还估计了单胺氧化酶（MAO）活性和Mn水平。锰治疗产生的DA水平和营业额在纹状体，但不是在大脑的其余部分下降。脑干和下丘脑NE含量增加。NE营业额在脑干中增加，在下丘脑中减少，在大脑的其余部分不变。在任何脑区，单胺氧化酶的活性都没有显著改变。这些结果表明，慢性管理的锰可能会导致区域不同的变化，在儿茶酚胺营业额，讨论了锰在脑区的积累和其他代谢变化与锰毒性。
Rats were treated with MnCl2.cntdot.4H2O (1 mg/100 g per day, i.p.) for 4 mo. The turnover of dopamine (DA) and norepinephrine (NE) was measured in several brain regions (brain stem, hypothalamus, corpus striatum and rest of the brain) by the decay in endogenous DA and NE after inhibition of tyrosine hydroxylase by .alpha.-methylparatyrosine. Monoamine oxidase (MAO) activity and Mn levels were also estimated. Mn treatment produced a decrease in DA level and turnover in the corpus striatum but not in the rest of the brain. An increase in contents of NE was observed in the brain stem and hypothalamus. NE turnover was increased in the brain stem, decreased in the hypothalamus and unaltered in the rest of the brain. MAO activity was not significantly altered in any brain region. These results, which showed that chronic administration of Mn may cause regionally different changes in catecholamine turnover, were discussed in relation to the accumulation of Mn in the brain regions and to other metabolic changes associated with Mn toxicity.