Tracking of Serum 25-Hydroxyvitamin D Levels During 14 Years in a Population-based Study and During 12 Months in an Intervention Study
Tracking of Serum 25-Hydroxyvitamin D Levels During 14 Years in a Population-based Study and During 12 Months in an Intervention Study
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DOI：
10.1093/aje/kwq005
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发表时间：
2010-04-15
影响因子：
5
通讯作者：
Grimnes, Guri
中科院分区：
文献类型：
--
作者：
Jorde, Rolf;Sneve, Monica;Grimnes, Guri
血清25-羟基维生素D （25(OH)D）水平低与心血管疾病的危险因素有关，而且它们似乎也可以预测2型糖尿病、癌症的后期发展和死亡率的增加。这些预测都是基于单一的25(OH)D测量，但到目前为止还没有关于追踪血清25(OH)D水平的已知报告。在目前的挪威研究中，测量了1994年和2008年特罗姆瑟调查中2668名受试者的血清25(OH)D水平，以及在维生素D干预研究中随机分配到安慰剂组的94名受试者，每三个月测量一次，持续一年。25(OH)D有明显的季节变化，根据季节调整方法，1994年和2008年血清25(OH)D的相关系数在0.42 ~ 0.52之间。在为期1年的干预研究中，基线值与12个月值的相关性为0.80，除了季节的影响外，体重、维生素D摄入量和体力活动的变化与血清25(OH)D水平的变化有关。血清25(OH)D的追踪与血压和血脂的追踪相似，它为使用单一25(OH)D测量来预测未来的健康结果提供了一些支持。
Low serum 25-hydroxyvitamin D (25(OH)D) levels are associated with risk factors for cardiovascular disease, and they also appear to predict later development of type 2 diabetes, cancer, and an increased mortality rate These predictions are all based on a single 25(OH)D measurement, but so far there are no known reports on tracking of serum 25(OH)D levels. In the present Norwegian study, serum 25(OH)D levels were measured 1) in 2,668 subjects in the 1994 and 2008 Tromso surveys and 2) every third month for 1 year in 94 subjects randomly assigned to placebo in a vitamin D intervention study. There was a marked seasonal variation in 25(OH)D, and, depending on the method of adjusting for season, the correlation coefficient between serum 25(OH)D measurements from 1994 and 2008 ranged from 0.42 to 0.52. In the 1-year intervention study, the correlation between baseline and 12-month values was 0.80 Apart from the effect of season, changes in weight, intake of vitamin D, and physical activity were related to change in serum 25(OH)D levels. Tracking of serum 25(OH)D appears similar to that for blood pressure and serum lipids, and it provides some support for the use of a single 25(OH)D measurement to predict future health outcomes.