ATROPHY OF MESIAL STRUCTURES IN PATIENTS WITH TEMPORAL-LOBE EPILEPSY - CAUSE OR CONSEQUENCE OF REPEATED SEIZURES
ATROPHY OF MESIAL STRUCTURES IN PATIENTS WITH TEMPORAL-LOBE EPILEPSY - CAUSE OR CONSEQUENCE OF REPEATED SEIZURES
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DOI：
10.1002/ana.410340607
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发表时间：
1993-12-01
影响因子：
11.2
通讯作者：
PETERS, T
中科院分区：
文献类型：
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作者：
CENDES, F;ANDERMANN, F;PETERS, T
我们通过使用磁共振成像体积测量杏仁核 (AM) 和海马结构 (HF) 对 70 名癫痫患者进行了研究。 50 名患者患有难治性颞叶癫痫 (TLE)，10 名患者患有局灶性颞叶外癫痫，10 名患者患有全身性癫痫。在 45 名没有外来组织病变的 TLE 患者中，91% 的 AM 和/或 HF 明显变小，与脑电图癫痫发作一侧一致。在局灶性颞外或全身性癫痫患者中未发现明显的小或不对称。我们进行了线性回归分析，绘制了复发性癫痫发作的年数和估计的癫痫发作频率与 AM 和 HF 体积的关系。这两个参数与 AM 或 HF 音量之间没有相关性 (p > 0.9)。患者的年龄和 AM 或 HF 的体积测量值之间也没有相关性，这些测量值也与全身性癫痫发作的发生无关。另一方面，与没有此类病史的患者相比，幼儿时期有过长期热性惊厥史的患者的 AM 和 HF 明显较小 (p < 0.001)。研究结果表明，反复发作或较长的癫痫持续时间不会导致可通过体积磁共振成像测量的 AM 或 HF 萎缩增加。
We studied 70 epileptic patients by using magnetic resonance imaging volumetric measurements of amygdala (AM) and hippocampal formation (HF). Fifty patients presented with intractable temporal lobe epilepsy (TLE), 10 patients had focal extratemporal lobe epilepsy, and 10 had generalized epilepsy. In 91% of the 45 TLE patients without foreign tissue lesions, there was significant smallness of the AM and/or HF coinciding with the side of electroncephalographic seizure onset. No significant smallness or asymmetry was demonstrated in patients with focal extratemporal or generalized epilepsy. We performed a linear regression analysis, plotting the number of years of recurrent seizures and the estimated seizure frequency against the volumes of the AM and HF. There was no correlation between either of these two parameters and AM or HF volume (p > 0.9). There was also no correlation between the patient's age and volumetric measurements of AM or HF, nor did these measurements correlate with the occurrence of generalized seizures. On the other hand, patients with antecedent prolonged febrile convulsions in early childhood had significantly smaller AM and HF, compared with those without such a history (p < 0.001). The findings indicate that repeated seizures or longer duration of epilepsy do not cause increased atrophy of AM or HF that is measurable by volumetric magnetic resonance imaging.