Integrated actions of renal medullary prostaglandins in the control of water excretion.
Integrated actions of renal medullary prostaglandins in the control of water excretion.
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DOI：
10.1152/ajprenal.1981.240.6.f471
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发表时间：
1981-06
期刊：
影响因子：
--
通讯作者：
J. Stokes
中科院分区：
文献类型：
--
作者：
J. Stokes
肾髓质是前列腺素的丰富来源。两种细胞类型，集合小管上皮细胞和间质细胞，具有制造前列腺素所必需的酶机制。由于这种局部产生和接近高度特化的髓质结构，前列腺素可以对髓质功能的几个方面发挥强有力的影响。至少有三种生理效应已被清楚地记录下来：降低抗利尿激素依赖性的收集小管上皮的渗透性，增强髓质血流量，抑制Henle’s袢厚升肢对NaCl的吸收。这三个功能是主要调节轴向溶质含量和水分排泄的功能。髓质前列腺素分泌增加的作用是降低髓质溶质含量，增加水排泄。在这方面的每一个行动。髓质前列腺素因此拮抗抗利尿激素的最终作用。除了对抗利尿激素依赖的渗透水流有直接拮抗作用外，前列腺素和抗利尿激素可能在其他部位也有拮抗作用。髓质前列腺素的这些作用为水排泄的“微调”提供了一个完整的机制。
The renal medulla is a rich source of prostaglandins. Two cell types, the collecting tubule epithelium and the interstitial cell, have the enzymatic machinery necessary to make prostaglandins. As a result of this localized production and the proximity to highly specialized medullary structures, the prostaglandins can exert potent effects on several aspects of medullary function. At least three physiologic effects have been clearly documented: reduction of vasopressin-dependent osmotic water permeability of the collecting tubule epithelium, enhancement of medullary blood flow, and inhibition of NaCl absorption from the thick ascending limb of Henle's loop. These three functions are the functions that primarily regulate axial solute content and water excretion. The effect of increasing medullary prostaglandin production is to reduce medullary solute content and increase water excretion. Each action in this regard. The medullary prostaglandins thus antagonize the ultimate action of vasopressin. In addition to the direct antagonistic effect on vasopressin-dependent osmotic water flow across the collecting tubule, prostaglandins and vasopressin may have antagonistic effects at other sites. These actions of medullary prostaglandins provide an integrated mechanism for the "fine tuning" of water excretion.