Modeling spatial and temporal dynamics of chemotactic networks.

Modeling spatial and temporal dynamics of chemotactic networks.
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模拟趋化网络的空间和时间动态。

DOI:
10.1007/978-1-60761-198-1_32
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发表时间:
2009
期刊:
Methods in molecular biology (Clifton, N.J.)
影响因子:
--
通讯作者:
Iglesias,PabloA
Iglesias,PabloA
中科院分区:
--
文献类型:
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作者:
Yang,Liu;Iglesias,PabloA

文献摘要

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当被化学引诱物刺激时,真核细胞通过时间和空间动态的组合来响应。这些反应是由于大量信号成分的相互作用而产生的。这些系统的复杂性使得如果没有系统地生成和测试假设的方法,就很难理解。计算机模拟已被证明是有用的测试概念模型。在这里,我们概述了开发这些模型所需的步骤。
When stimulated by chemoattractants, eukaryotic cells respond through a combination of temporal and spatial dynamics. These responses come about because of the interaction of a large number of signaling components. The complexity of these systems makes it hard to understand without a means of systematically generating and testing hypotheses. Computer simulations have proved to be useful in testing conceptual models. Here we outline the steps required to develop these models.