2019 novel coronavirus (2019-nCoV) outbreak: A new challenge
2019 novel coronavirus (2019-nCoV) outbreak: A new challenge
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DOI：
10.1016/j.jgar.2020.02.021
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发表时间：
2020-06-01
影响因子：
4.6
通讯作者：
Corcione, Silvia
中科院分区：
文献类型：
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作者：
Lupia, Tommaso;Scabini, Silvia;Corcione, Silvia
目的：继世界卫生组织（世卫组织）于2020年1月30日宣布发生国际关注的突发公共卫生事件（PHEIC）以及最近由2019年新型冠状病毒引起的疫情后，（2019-nCoV）[正式更名为严重急性呼吸综合征冠状病毒2型（SARS-CoV-2）]在中国和其他29个国家，我们的目的是总结新型β冠状病毒病的临床方面（COVID-19）及其可能的临床表现，以及为可能需要抗菌治疗的患者建议的治疗方案。研究方法：在撰写本文时（2020年2月13日），对目前可用的文献进行了审查，以了解2019-nCoV或COVID-19微生物确认的感染。使用PubMed数据库和科克伦图书馆进行文献检索。检索词包括“新型冠状病毒”或“2019- nCoV”或“COVID-19”。结果：已发表的病例主要发生在男性（年龄范围，8-92岁）。心血管、消化系统和内分泌系统疾病的报告较为普遍，但既往慢性肺病[如慢性阻塞性肺病（COPD）、哮喘、支气管扩张症]的报告率低得惊人。所有可用病例系列均存在发热，伴有咳嗽、呼吸困难、肌痛和疲乏。多个双侧小叶和亚段实变区或双侧毛玻璃样阴影是2019-nCoV感染的主要放射学特征，至少在疾病的早期阶段是如此。结论：2019-nCoV新发疫情主要与呼吸系统疾病相关，肺外体征较少。然而，相关的既存呼吸系统合并症的发生率较低。(C)2020年由爱思唯尔有限公司代表国际抗微生物化疗学会发布。
Objectives: Following the public -health emergency of international concern (PHEIC) declared by the World Health Organization (WHO) on 30 January 2020 and the recent outbreak caused by 2019 novel coronavirus (2019-nCoV) [officially renamed severe acute respiratory syndrome coronavirus 2 (SARS- CoV-2)] in China and 29 other countries, we aimed to summarise the clinical aspects of the novel Betacoronavirus disease (COVID-19) and its possible clinical presentations together with suggested therapeutic algorithms for patients who may require antimicrobial treatment. Methods: The currently available literature was reviewed for microbiologically confirmed infections by 2019-nCoV or COVID-19 at the time of writing (13 February 2020). A literature search was performed using the PubMed database and Cochrane Library. Search terms included 'novel coronavirus' or '2019- nCoV' or 'COVID-19'. Results: Published cases occurred mostly in males (age range, 8-92 years). Cardiovascular, digestive and endocrine system diseases were commonly reported, except previous chronic pulmonary diseases [e.g. chronic obstructive pulmonary disease (COPD), asthma, bronchiectasis] that were surprisingly underreported. Fever was present in all of the case series available, flanked by cough, dyspnoea, myalgia and fatigue. Multiple bilateral lobular and subsegmental areas of consolidation or bilateral ground -glass opacities were the main reported radiological features of 2019-nCoV infection, at least in the early phases of the disease. Conclusion: The new 2019-nCoV epidemic is mainly associated with respiratory disease and few extrapulmonary signs. However, there is a low rate of associated pre-existing respiratory co -morbidities. (C) 2020 Published by Elsevier Ltd on behalf of International Society for Antimicrobial Chemotherapy.