Synthetic studies on the pederin family of antitumour agents. Syntheses of mycalamide B, theopederin D and pederin
Synthetic studies on the pederin family of antitumour agents. Syntheses of mycalamide B, theopederin D and pederin
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DOI：
10.1039/a909898d
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发表时间：
2000-01-01
期刊：
影响因子：
--
通讯作者：
Boyle, FT
中科院分区：
文献类型：
--
作者：
Kocienski, P;Narquizian, R;Boyle, FT
抗肿瘤药物Pederin家族成员的通用模块化方法的例子是mycalamine B和theopederin D的合成以及pederin的正式合成。这三种化合物都是从6-lithio-2，3-dimethyl-4-phenylselenomethyl-3，4-dihydro-2H-pyran和2-(3-chloropropyl)-3，3-dimethyl-3，4-dihydro-2H-pyran-4-one.制备的
A general modular approach to the members of the pederin family of antitumour agents is exemplified by syntheses of mycalamide B and theopederin D as well as a formal synthesis of pederin. All three compounds are prepared from 6-lithio-2,3-dimethyl-4-phenylselenomethyl-3,4-dihydro-2H-pyran and 2-(3-chloropropyl)-3,3-dimethyl-3,4-dihydro-2H-pyran-4-one.